Barking up the wrong tree: MicroRNAs in bile as markers for biliary complications

Verhoeven, Cornelia J.; Metselaar, Herold J.; Laan, Luc J. W. van der

doi:10.1002/lt.23898

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Moreover, CDmiRs were shown to be predictive of severe biliary injury already at time of graft preservation in LT (20); in contrast to HDmiRs, grafts that developed biliary complications following LT contained lower levels of CDmiRs in perfusates. These findings suggest that during injury, there is a polarized release of HDmiRs and CDmiRs by hepatocytes and cholangiocytes (21).…”

mentioning

confidence: 82%

Polarized release of hepatic microRNAs into bile and serum in response to cellular injury and impaired liver function

Verhoeven

Farid

Roest

et al. 2015

Liver International

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mentioning

confidence: 82%

Polarized release of hepatic microRNAs into bile and serum in response to cellular injury and impaired liver function

Verhoeven

Farid

Roest

et al. 2015

Liver International

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“…They suggest that analysis of distinct fractions of biliary miRNAs is more likely to be informative for pathophysiological mechanisms related to biomarker release, which could increase its sensitivity and specificity as a biomarker. (63) Cytomegalovirus (CMV ) is the most common viral infectious pathogen in LT recipients. Before CMV prophylaxis, CMV infection was a risk for biliary complications after LT. A study investigated CMV DNA in biliary samples from 124 transplant recipients.…”

Section: Review Article | 1185mentioning

confidence: 99%

Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation

2020

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Bile secretion and composition reflects the functional status of hepatocytes and cholangiocytes. Bile composition can have a role in the assessment of donor grafts before implantation in the recipient. In addition, changes in bile composition after liver transplantation can serve as a diagnostic and prognostic tool to predict posttransplant complications, such as primary nonfunction, acute cellular rejection, or nonanastomotic biliary strictures. With the popularization of liver machine perfusion preservation in the clinical setting, there is a revisited interest in biliary biomarkers to assess graft viability before implantation. This review discusses current literature on biliary biomarkers that could predict or assess liver graft and bile duct viability. Bile composition offers an exciting and novel perspective in the search for reliable hepatocyte and cholangiocyte viability biomarkers.

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“… showed that bile levels of miR‐517a, miR‐892a, and miR‐106a* were increased in patients with ischemic cholangiopathy and could distinguish between ischemic cholangiopathy and other causes for biliary obstructions. In particular for biliary complications, miRNA composition in bile rather than serum might better reflect ongoing injury of cholangiocytes .…”

Section: Circulating Micrornas As Noninvasive Biomarkers In Liver Tramentioning

confidence: 99%

The ins and outs of microRNAs as biomarkers in liver disease and transplantation

et al. 2014

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Summary Ongoing research is being conducted in the field of transplantation to discover novel, noninvasive biomarkers for assessment of graft quality before transplantation and monitoring of graft injury after transplantation. MicroRNAs (miRNAs) are among the most promising in this field. MiRNAs are small noncoding RNAs that function as important regulators of gene expression in response to cellular stress and disease. An advantage that makes miRNAs attractive candidates for biomarker research is their fast release from cells in response to stress and injury, which can occur via different routes. In the context of liver transplantation (LT), noninvasive measurement and stability of extracellular miRNAs in blood, bile, and graft perfusates has been linked to cell‐type specific injury and early graft outcome following LT. Furthermore, specific intrahepatic miRNA expression patterns have been associated with graft survival and recurrent disease, like hepatitis C virus‐related fibrosis and hepatocellular carcinoma. Therefore, miRNAs with strong predictive value and high sensitivity and specificity might be successfully applied to assess hepatic injury and to diagnose (recurrent) liver disease before, during and after LT. In this review, the current features and future prospects of miRNAs as biomarkers in and out of the liver are discussed.

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Barking up the wrong tree: MicroRNAs in bile as markers for biliary complications

Cited by 5 publications

References 28 publications

Polarized release of hepatic microRNAs into bile and serum in response to cellular injury and impaired liver function

Polarized release of hepatic microRNAs into bile and serum in response to cellular injury and impaired liver function

Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation

The ins and outs of microRNAs as biomarkers in liver disease and transplantation

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