Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies

Abstract

Magnesium silicate (MgS) nanopowders doped with barium oxide (BaO) were prepared by sol-gel technique, which were then implanted into a fracture of a tibia bone in rats for studying enhanced in vivo bone regeneration. The produced nanopowders were characterized using X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), scanning electron microscope with energy-dispersive X-ray spectrometry (SEM-EDX) and transmission electron microscope (TEM). Mechanical and bactericidal properties of the nanopowders were also determined. Increased crystallinity, particle diameter and surface area were found to decrease after the BaO doping without any notable alterations on their chemical integrities. Moreover, elevated mechanical and antibacterial characteristics were recognized for higher BaO doping concentrations. Our animal studies demonstrated that impressive new bone tissues were formed in the fractures while the prepared samples degraded, indicating that the osteogenesis and degradability of the BaO containing MgS samples were better than the control MgS. The results of the animal study indicated that the simultaneous bone formation on magnesium biomaterial silicate and barium MgS with completed bone healing after five weeks of implantations. The findings also demonstrated that the prepared samples with good biocompatibility and degradability could enhance vascularization and osteogenesis, and they have therapeutic potential to heal bone fractures.

Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis

“…This not only helps patients recover after surgery but also decreases the workload of surgeons and increases the efficiency and quality of care (Liu C et al,2022a). However, traditional biodegradable polymers suffer from insufficient strength and low modulus of elasticity, limiting their application on a large scale (Mabrouk et al,2022). In this regard, the use of biodegradable magnesium-based materials eliminates the issues of stress shielding effect, foreign body reaction, and lack of strength, and their clinical safety and efficacy offer significant advantages over conventional polymer materials (Martin et al,2022).…”

The Effect of a Wheat Protein-based Magnesium Silicate Hydrogel Loaded with a Glucosamine Composite on the Regeneration of Cartilage

“…Magnesium silicate (MS) is a synthesized silicate that consists of silicon and magnesium. The MS composite has been studied in the eld of bone fracture healing and ligament grafting, and it has shown satisfactory performance [23,24]. Silicon can promote the synthesis of collagen and proteoglycans in bone and cartilage [25].…”

New 3D Printed Scaffolds Based on Walstromite Synthesized by Sol–Gel Method

“…Recently, significant attention has been directed toward the role of barium in bone repair and regeneration, particularly in the context of osteogenesis [24][25][26]. It has been demonstrated that the incorporation of Ba 2+ into bioceramic compositions enhances the mineralization of their surfaces under in vitro conditions, as observed during immersion in simulated body fluid (SBF) [26][27][28][29][30]. One such oxide ceramic mineral phase, which includes silicon, calcium, and barium, is known as walstromite.…”