Barium Ions Crosslinked Alginate and Sterculia Gum-Based Gastroretentive Floating Drug Delivery System for Use in Peptic Ulcers

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

“…4) [23,[38][39][40][41][42] . These physical interactions are reversible in nature, i.e., the physical interactions breakdown causing a loss of structural integrity when suitable energy (e.g., mechanical stress and thermal energy) is provided and regain the original structure when the energy is withdrawn [43] .…”

Encapsulated eucalyptus oil in ionically cross-linked alginate microcapsules and its controlled release

“…The cross-linking reaction of sodium alginate with CaCl 2 is based on the formation of a tight junction between the guluronic acid residues. Ca 2+ ions, with an atomic size of 1.14Å, form a twodimensional bonding structure with sodium alginate inside the alginate matrix (Kaygusuz, Erim, Pekcan, & Evingur, 2014;Singh & Chauhan, 2011). Increasing the CaCl 2 concentration increases the alginate gel density and so affects the pore size within the gel.…”

SterculiaandBrachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

“…Two alkaloids, including sterculinine I (115) and sterculinine II (116), were isolated from the seeds of S. lychnophora [91] ; caffeine (117) was isolated from B. luridum (S. lurida). [92] S. lychnophora seeds were the main source for cerebrosides isolated from the genus (118)(119)(120). [11,91] Furthermore, carboxylic acids were isolated from several species such as ascorbic acid (121) which was isolated from S. foetida and S. urens, [108] while succinic acid (122) was isolated from S. lychnophora.…”

“…[92] S. lychnophora seeds were the main source for cerebrosides isolated from the genus (118)(119)(120). [11,91] Furthermore, carboxylic acids were isolated from several species such as ascorbic acid (121) which was isolated from S. foetida and S. urens, [108] while succinic acid (122) was isolated from S. lychnophora.…”

“…[117] The gum enhanced the repair of gastric mucosa, so it was used in the formulation of gastroretentive drug-delivery system containing pantoprazole which is used for the treatment of peptic ulcer. [118] A hydrogel for the treatment of diarrhoea was formulated using S. urens gum and ornidazole; both of them proved to possess antidiarrhoeal properties. [119] Moreover, Sterculia gum was evaluated as a hydrogel matrix in dressings containing tetracycline antibiotic used for wound healing.…”