Bariatric surgery-induced weight loss: Does it have any impact on serum cystatin C levels?

Salgado, João Victor; Salgado, Bernardete Jorge

doi:10.1016/j.soard.2013.08.007

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…However, some reports show that there is an association between obesity and elevated serum cystatin C levels [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Can Bariatric Surgery Be a Surgical Treatment to Prevent the Progression of Chronic Kidney Disease?

Choi

2016

J Metab Bariatr Surg

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Obesity is a serious worldwide health problem causing numerous obesity-related comorbidities such as hyperlipidemia, hypertension, diabetes, and cardiovascular dysfunctions. Recently, many studies indicate that obesity is strongly related with high rate of renal lesions and reducing weight with surgical intervention can improve renal parameters in obese patients, but the effect of bariatric surgery on obesity-induced chronic kidney disease (CKD) is hardly documented. This review study shows that bariatric surgery demonstrates beneficial reduction in proteinuria and albuminuria leading to improve both glomerular hyperfiltration and chronic kidney disease in obese population. Yet, bariatric surgery is not a definite treatment of choice for the obese patients with CKD because of lack of evidence explaining the risk of complications following bariatric surgery and clarification on estimating glomerular filtration rate (eGFR) in obese patients. Future, high quality studies with a long term follow up are required to determine the effective durability of bariatric surgery on obese-related CKD patients.

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“…However, some reports show that there is an association between obesity and elevated serum cystatin C levels [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Can Bariatric Surgery Be a Surgical Treatment to Prevent the Progression of Chronic Kidney Disease?

Choi

2016

J Metab Bariatr Surg

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“…Yet, cystatin C has shown to be as good as or even better as a predictor of GFR [ 19 , 20 ] because it is independent of muscle mass [ 20 , 21 ] and it is less prone to being influenced by body composition [ 4 ]. On the other hand, some studies have reported an association between obesity and elevated serum cystatin C levels [ 14 , 22 , 23 ]. However, the contribution of adipose tissue in this association is not clear.…”

Section: Introductionmentioning

confidence: 99%

Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease

França

Santos

Salgado

et al. 2014

International Journal of Nephrology

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Information on the association between obesity and initial phases of chronic kidney disease (CKD) is still limited, principally those regarding the influence of visceral adipose tissue. We investigated whether the visceral adipose tissue is more associated with reductions in glomerular filtration rate (GFR) than total and abdominal obesity in hypertensive individuals with stage 1-2 CKD. A cross-sectional study was implemented which involved 241 hypertensive patients undergoing treatment at a primary health care facility. GFR was estimated using equations based on creatinine and cystatin C levels. Explanatory variables included body mass index (BMI), waist circumference (WC), and estimated visceral adipose tissue (eVAT). The mean age was 59.6 ± 9.2 years old and 75.9% were female. According to BMI, 28.2% of subjects were obese. Prevalence of increased WC and eVAT was 63.9% and 58.5%, respectively. Results from the assessment of GFR by BMI, WC, and eVAT categories showed that only women with increased eVAT (≥150 cm2) had a lower mean GFR by Larsson (P = 0.016), Levey 2 (P = 0.005), and Levey 3 (P = 0.008) equations. The same result was not observed when the MDRD equation was employed. No association was found between BMI, WC, eVAT, and GFR using only serum creatinine. In the early stages of CKD, increased eVAT in hypertensive women was associated with decreased GFR based on cystatin C.

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Bariatric surgery-induced weight loss: Does it have any impact on serum cystatin C levels?

Cited by 2 publications

References 5 publications

Can Bariatric Surgery Be a Surgical Treatment to Prevent the Progression of Chronic Kidney Disease?

Can Bariatric Surgery Be a Surgical Treatment to Prevent the Progression of Chronic Kidney Disease?

Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease

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