Bariatric Surgery in NAFLD

Chauhan, Mahak; Singh, Kuldeep; Thuluvath, Paul J.

doi:10.1007/s10620-021-07317-3

Cited by 28 publications

(24 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10 Vertical sleeve gastrectomy and RYGB in animal models are associated with increased levels of serum bile acids, likely because of increased absorption and gut microbiome changes. 8 Bile acids, which bind to G proteincoupled BA receptor 1 (TGR5) and farnesoid-X receptor receptors, have long been known to assist in energy homeostasis, cholesterol metabolism, and lipid digestion.…”

Section: Mechanisms Of Nafld I Mprovement Through Bari Atric Surgerymentioning

confidence: 99%

“…Proposed mechanisms of these metabolic changes include alterations in bile homeostasis, changes in gastrointestinal hormones, changes in eating habits, improvement of type 2 diabetes, and shifts in the gut microbiota. 8 Bariatric surgery may lead to increased delivery to bile acids to the terminal ileum, stimulating endocrine L cells to release incretins such as glucagon-like peptide 1 (GLP-1) and satiety gut hormones such as peptide YY (PYY). 9 Release of PYY and GLP-1 then activates anorexigenic pathways and increases insulin production, release, and sensitivity, thereby ameliorating type 2 diabetes.…”

Section: Mechanisms Of Nafld I Mprovement Through Bari Atric Surgerymentioning

confidence: 99%

“…Aside from sustained weight loss over the long term, bariatric surgery improves NAFLD through metabolic changes that occur early in the postprocedure period (see Figure 2). Proposed mechanisms of these metabolic changes include alterations in bile homeostasis, changes in gastrointestinal hormones, changes in eating habits, improvement of type 2 diabetes, and shifts in the gut microbiota 8 …”

Section: Mechanisms Of Nafld Improvement Through Bariatric Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Improvement in nonalcoholic fatty liver disease through bariatric surgery

Truong

Noureddin

2022

Clinical Liver Disease

View full text Add to dashboard Cite

Section: Mechanisms Of Nafld I Mprovement Through Bari Atric Surgerymentioning

confidence: 99%

Section: Mechanisms Of Nafld I Mprovement Through Bari Atric Surgerymentioning

confidence: 99%

Section: Mechanisms Of Nafld Improvement Through Bariatric Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Improvement in nonalcoholic fatty liver disease through bariatric surgery

Truong

Noureddin

2022

Clinical Liver Disease

View full text Add to dashboard Cite

“…By now, there are many ongoing clinical trials of pharmacotherapies for the treatment of NASH, including CCR2/5 inhibitor, PPARa/d ligand, FXR ligand/agonist, and ASK-1 inhibitor (1). In addition to drugs, bariatric surgery has been proven to be another powerful therapeutic method for NAFLD and NASH (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Increased plasma genistein after bariatric surgery could promote remission of NAFLD in patients with obesity

Wang

Wang²,

Bai³

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundBariatric surgery is associated with a positive effect on the progress of non-alcoholic associated fatty liver disease (NAFLD). Although weight loss is the obvious mechanism, there are also weight-independent mechanisms.MethodsWe collected blood samples from 5 patients with obesity before and 3 months after surgery and performed an LC-MS-based untargeted metabolomics test to detect potential systemic changes. We also constructed sleeve gastrectomy (SG) mice models. The plasma, liver and intestine samples were collected and analyzed by qPCR, ELISA and HPLC. Cohousing experiments and feces transplantation experiments were performed on mice to study the effect of gut microbiota. Genistein administration experiments were used to study the in vivo function of the metabolites.ResultsPlasma genistein (GE) was identified to be elevated after surgery. Both clinical data and rodent models suggested that plasma GE is negatively related to the degree of NAFLD. We fed diet-induced obese (DIO) mice with GE, and we found that there was significant remission of NAFLD. Both in vivo and in vitro experiments showed that GE could restrict the inflammation state in the liver and thus relieve NAFLD. Finally, we used co-housing experiments to alter the gut microbiota in mice, and it was identified that sleeve gastrectomy (SG) mice had a special gut microbiota phenotype, which could result in higher plasma GE levels. By feces transplantation experiment (FMT), we found that only feces from the SG mice (and not from other lean mice) could induce higher plasma GE levels.ConclusionOur studies showed that SG but not calorie restriction could induce higher plasma GE levels by altering the gut microbiota. This change could promote NAFLD remission. Our study provides new insights into the systemic effects of bariatric surgery. Bariatric surgery could affect remote organs via altered metabolites from the gut microbiota. Our study also identified that additional supplement of GE after surgery could be a therapy for NAFLD.

show abstract

“…These data indicate that NAFLD has become one of the major public health problems in the world [3]. The main treatment methods for NAFLD currently include the following: (1) lifestyle changes; (2) drug therapy with pioglitazone, silymarin, and liraglutide, among other drugs; and (3) surgical intervention [4]. However, all of the aforementioned treatment methods have limitations, and additional treatment methods, such as drugs with few side effects and good efficacy, urgently need to be developed for the treatment of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Marine Chitooligosaccharide Alters Intestinal Flora Structure and Regulates Hepatic Inflammatory Response to Influence Nonalcoholic Fatty Liver Disease

et al. 2022

View full text Add to dashboard Cite

In this study, C57BL/6 mice were given an HFHSD diet for 8 weeks to induce hepatic steatosis and then given COSM solution orally for 12 weeks. The study found that the HFHSD diet resulted in steatosis and insulin resistance in mice. The formation of NAFLD induced by HFHSD diet was related to the imbalance of intestinal flora. However, after COSM intervention, the abundance of beneficial bacteria increased significantly, while the abundance of harmful bacteria decreased significantly. The HFHSD diet also induced changes in intestinal bacterial metabolites, and the content of short-chain fatty acids in cecal contents after COSM intervention was significantly higher than that in the model group. In addition, COSM not only improved LPS levels and barrier dysfunction in the ileum and colon but upregulated protein levels of ZO-1, occludin, and claudin in the colon and downregulated the liver LPS/TLR4/NF-κB inflammatory pathway. We concluded that the treatment of marine chitooligosaccharide COSM could improve the intestinal microflora structure of the fatty liver and activate an inflammatory signaling pathway, thus alleviating the intrahepatic lipid accumulation induced by HFHSD.

show abstract

Bariatric Surgery in NAFLD

Cited by 28 publications

References 117 publications

Improvement in nonalcoholic fatty liver disease through bariatric surgery

Improvement in nonalcoholic fatty liver disease through bariatric surgery

Increased plasma genistein after bariatric surgery could promote remission of NAFLD in patients with obesity

Marine Chitooligosaccharide Alters Intestinal Flora Structure and Regulates Hepatic Inflammatory Response to Influence Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About