Bariatric Surgery Improves Hyperandrogenism, Menstrual Irregularities, and Metabolic Dysfunction Among Women with Polycystic Ovary Syndrome (PCOS)

Christ, Jacob; Falcone, Tommaso

doi:10.1007/s11695-018-3155-6

Cited by 60 publications

(45 citation statements)

References 37 publications

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“…Our research has indicated that women of reproductive age attain body weight stability at 12 months, which indicates a mesomeric state suitable for pregnancy. Previous studies have shown that, in obese women with polycystic ovary syndrome, hormones such as estrogen and progestogen achieve a normalized balance as early as 3 months after bariatric surgery, which has led to unplanned pregnancies (17). Therefore, guidelines for bariatric surgery often suggest that pregnancy be avoided during the first 18-24 months postoperatively-which is generally based on consensus instead of evidence (18).…”

Section: Discussionmentioning

confidence: 99%

Timing of Maximal Weight Reduction Following Bariatric Surgery: A Study in Chinese Patients

Wang

Zhang

et al. 2020

Front. Endocrinol.

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Introduction: Bariatric surgery is a well-received treatment for obesity with maximal weight loss at 12-36 months postoperatively. We investigated the effect of early bariatric surgery on weight reduction of Chinese patients in accordance with their preoperation characteristics. Materials and Methods: Altogether, 409 patients with obesity from a prospective cohort in a single bariatric center were enrolled retrospectively and evaluated for up to 4 years. Measurements obtained included surgery type, duration of diabetic condition, besides the usual body mass index data tuple. Weight reduction was expressed as percent total weight loss (%TWL) and percent excess weight loss (%EWL). Results: RYGB or SG were performed laparoscopically without mortality or complications. BMI generally plateaued at 12 months, having decreased at a mean of 8.78 kg/m 2. Successful weight loss of >25% TWL was achieved by 35.16, 49.03, 39.22, 27.74, 20.83% of patients at 6, 12, 24, 36, and 48 months after surgery. Overall, 52.91% of our patients had lost 100% of their excess weight at 12 months, although there was a rather wide range among individuals. Similar variability was revealed in women of child-bearing age. Conclusion: Chinese patients undergoing bariatric surgery tend to achieve maximal weight loss and stabilization between 12 and 24 months postoperatively, instead of at >2 years. The finding of the shorter stabilization interval has importance to earlier intervention of weight loss related conditions and women's conception planning.

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Section: Discussionmentioning

confidence: 99%

Timing of Maximal Weight Reduction Following Bariatric Surgery: A Study in Chinese Patients

Wang

Zhang

et al. 2020

Front. Endocrinol.

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“…Substantial reductions in BMI and lipid profile were noted postoperatively (P<0.05) [31]. Patients' androgen levels also significantly decreased (P<0.05) such that the percentage meeting the criteria for hyperandrogenism and irregular menses subsequently dropped (P<0.05) [31]. However, ovarian volume (OV) was not seen as significantly declining postoperatively [31].…”

Section: Reviewmentioning

confidence: 96%

Section: Reviewmentioning

confidence: 99%

“…Christ and Falcone performed a review on 44 women with PCOS regarding the impact of bariatric surgery on metabolic and hormone levels and its predicted benefits post-operation [31]. Substantial reductions in BMI and lipid profile were noted postoperatively (P<0.05) [31]. Patients' androgen levels also significantly decreased (P<0.05) such that the percentage meeting the criteria for hyperandrogenism and irregular menses subsequently dropped (P<0.05) [31].…”

Section: Reviewmentioning

confidence: 99%

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A Review of the Impact of Bariatric Surgery in Women With Polycystic Ovary Syndrome

Lee¹,

Mathew²,

Jose³

et al. 2020

Cureus

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Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in reproductive-age women that causes infertility. Obesity and insulin resistance are closely tied to the pathophysiology of PCOS. Current first-line treatments include lifestyle modifications, hormone modulators, and laparoscopic ovarian drilling, but little attention has been given to bariatric surgery as a viable option. A detailed review of the literature regarding the outcomes of obese women with PCOS after bariatric surgery is necessary. All studies were found in the PubMed database, limited to females and humans, and selected due to relevancy and quantitative data. Bariatric surgery promotes significant weight loss within one year, which is associated with amelioration of insulin resistance, hyperandrogenism, menstrual irregularity, and ovulatory dysfunction. Surgery successfully mediates the regression of PCOS and promotes successful pregnancy. Thus, we recommend the consideration of bariatric surgery as part of the main treatment considerations in obese patients with PCOS. However, more focused and comprehensive research with better study designs are still needed in the future to investigate PCOS and bariatric surgery.

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“…In a subsequent survey, the authors found a significant reduction of ovarian volume in severely obese women suffering from PCOS after bariatric surgery. The authors concluded that bariatric surgery improves key diagnostic features in women with PCOS and hyperandrogenism [89,90]. Another survey with a follow-up of four years confirmed the persistence of these hormonal changes.…”

Section: Sexual Hormones and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 89%

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

Jäger

Wolicki

Spohnholz

et al. 2020

IJERPH

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This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary incontinence; female-specific cancer; and metabolism, outcome, and quality of life. For each category, the current status of research is illuminated and implications for bariatric treatment are determined. A summary that includes key messages is given for each subsection. An overall result of this paper is an understanding that sex-specific risks that follow or result from bariatric surgery should be considered more in aftercare. In order to increase the evidence, further research focusing on sex-specific differences in the outcome of bariatric surgery and promising treatment approaches to female-specific diseases is needed. Nevertheless, bariatric surgery shows good potential in the treatment of sex-specific aspects for severely obese women that goes far beyond mere weight loss and reduction of metabolic risks.

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Bariatric Surgery Improves Hyperandrogenism, Menstrual Irregularities, and Metabolic Dysfunction Among Women with Polycystic Ovary Syndrome (PCOS)

Abstract: Bariatric surgery improves key diagnostic features seen in women with PCOS and ovarian volume, and free testosterone may have utility in predicting likelihood of metabolic benefit from surgery.

Cited by 60 publications

References 37 publications

Timing of Maximal Weight Reduction Following Bariatric Surgery: A Study in Chinese Patients

Timing of Maximal Weight Reduction Following Bariatric Surgery: A Study in Chinese Patients

A Review of the Impact of Bariatric Surgery in Women With Polycystic Ovary Syndrome

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

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