Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions

Abstract

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Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

“…The resulting emulsion is an O/W emulsion with a droplet size of ≈ 2 to 15 µm. In previous works[38,220,221], our team used PLGA-PVA (poly(vinyl alcohol)) NP and PLGA NP (≈ 200 nm) to stabilize emulsions prepared with biocompatible oils (Miglyol 812N and Lipiodol). Albert et al[38] formulated emulsions with bare PLGA NP on the one hand (i.e.…”

Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties

“…Preliminary results suggested that PLGA-PVA NPs had similar characteristics, whatever the PLGA type. Indeed, a previous publication of our group suggested that PVA governs the characteristics of PLGA-PVA NPs [6], so it was decided to prepare PLGA-PVA NPs with only one PLGA type to reduce the number of studied systems. An ester-ending polymer (PLGA 753 S) was chosen, as it is more hydrophobic, to emphasise the potential effect of the hydrophilic PVA coverage on the characteristics of NPs.…”

“…The amount of PVA adsorbed at the PLGA-PVA NP surface after purification was indirectly measured by determining the PVA concentration in the supernatant after the centrifugation step of the emulsion-evaporation preparation process. This method, described in a previous publication [6], is based on the formation of a green-coloured complex between PVA and iodine in presence of boric acid. The supernatant was diluted with purified water so that PVA concentrations were within the range of the calibration curve (5 to 50 μg/mL of PVA).…”

“…In a previous work, we have demonstrated the interest of using poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) as stabilisers for Pickering emulsions [6]. PLGA is one of the most attractive polymer for the formulation of biocompatible pharmaceutical systems [7,8].…”

Core‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells

“…DPPC is the main component of thermosensitive liposomes, which can generate a gel-to-liquid phase transition in response to local hyperthermia (41.5–41.9°C), thus triggering the release of a large amount of drug (22,23). PLGA, approved by the U.S. Food and Drug Administration, is a promising biocompatible and degradable polymer that can be rapidly removed from the body, and is an ideal nanomaterial for drug delivery (24,25). Li et al (26) designed a delivery system consisting of a DOX-modified PLGA core surrounded by a DPPC shell to treat breast cancer.…”