In this single-center study, we found that a new prognostic scale, the Barcelona Bio-Heart Failure Risk Calculator (BCN), performs significantly better than traditional prognostic scores, such as the Heart Failure Survival Score (HFSS) and the Seattle Heart Failure Model (SHFM), in patients with end-stage heart failure. Lower BCN and HFSS scores are independently associated with a higher risk of one-year mortality in the analyzed population.