Barbiturates–Structure Versus RIA Reactivity

Budd, Robert D.; Yang, Felisa C.; Utley, Keith O.

doi:10.3109/15563658108990041

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Conversion Of Phb To Primidone1

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2013

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Cited by 6 publications

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“…11 It has never been described in patients, not even in high overdoses. Through extensive searches of Medline, Pubmed, and Google, we found one reference that mentions the possibility in an in vitro setting.…”

Section: Conversion Of Phb To Primidonementioning

confidence: 99%

A Child Exposed to Primidone Not Prescribed for Her

Tanoshima

Jong²,

Merlocco³

et al. 2013

Therapeutic Drug Monitoring

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A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents denied history of primidone administration. We wished to rule out intentional unprescribed use of primidone. Our retrospective review showed 3 other children with high PHB concentrations where primidone was also detected when PHB levels were over 130 μmol/L. Complementary studies confirmed that high-dose PHB can convert to its prodrug primidone, which has not been reported previously.

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Section: Conversion Of Phb To Primidonementioning

confidence: 99%