Barbiturate Anesthesia an Abnormal Physiologic Situation

Priano, Lawrence L.; Traber, D. L.; Wilson, Roy D.

doi:10.1097/00132586-197004000-00019

Cited by 22 publications

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“…Em cães de médio porte, como aqueles por nós utilizados, a freqüência cardíaca normal situa-se na faixa de 60 a 120 batimentos por minuto 15 . Verificamos que os animais apresentaram-se taquicárdicos no momento controle e nos períodos iniciais do experimento, quando estavam sob ação do pentobarbital sódico, droga que eleva a freqüência cardíaca, seja por liberação de catecolaminas ou por mediação de reflexos gerados em barorreceptores arteriais 16,17 . Também devemos ressaltar o fato dos animais serem submetidos à laparotomia para esplenectomia que deixaram os cães ainda mais taquicárdicos 18 .…”

Section: Discussionunclassified

Comportamento hemodinâmico e metabólico do choque hemorrágico: estudo experimental no cão

Meletti¹,

Módolo²

2003

Rev. Bras. Anestesiol.

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RESUMOMeletti JFA, Módolo NSP -Comportamento Hemodinâmico e Metabólico do Choque Hemorrágico: Estudo Experimental no Cão J U S T I F I C AT I VA E O B J E T I V O S : D i v e r s o s m o d e l o s experimentais têm sido utilizados para ilustrar as alterações hemodinâmicas e metabólicas que ocorrem durante o choque hemorrágico. O objetivo da pesquisa é o de observar os c o m p o r ta m e n t o s h e m o d i n â m i c o s e me ta b ó l i c o s q u

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Section: Discussionunclassified

Comportamento hemodinâmico e metabólico do choque hemorrágico: estudo experimental no cão

Meletti¹,

Módolo²

2003

Rev. Bras. Anestesiol.

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“…Anaesthetics affect a number of autonomic and haemodynamic parameters (Alper & Flacke, 1969;Priano et at., 1969;Balis & Monroe, 1964;Price, 1960;Garfield, Alper, Gillis & Flacke, 1968). Few investigators, however, have considered how the responsiveness of the cardiovascular system to drugs in the conscious animal is influenced by these agents.…”

Section: Discussionmentioning

confidence: 99%

“…Each of these agents causes specific alterations in various haemodynamic parameters (Alper & Flacke, 1969;Priano, Traber & Wilson, 1969;Balis & Monroe, 1964;Brown & Hilton, 1956). In addition, responses to cardiovascular drugs may differ qualitatively when tested under different anaesthetic agents (Giles & Burch, 1971).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics

Brezenoff

1973

British J Pharmacology

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Summary1. Cardiovascular responses to intravenously administered noradrenaline were monitored in the rat in the conscious state and again following anaesthesia. Injections and pressure recordings were made via permanently implanted venous and arterial catheters. 2. The pressor response to noradrenaline was inhibited by diethyl ether, urethane and deep pentobarbitone anaesthesia. It was unchanged by ketamine and was potentiated by chloralose and light pentobarbitone anaesthesia. 3. Reflex bradycardia was potentiated by chloralose, blocked by ketamine and reduced by pentobarbitone. It was either reduced or unchanged by ether or urethane.

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“…Recently the barbiturate anesthetized dog has been criticized as a model of normal cardiovascular physiology. [11] Since no study can be found in the literature reporting the influence of anesthesia on the efficacy of electrical defibrillation, a reasonable question may be raised about the validity of anesthetized animal models used for defibrillation studies.…”

Section: Introductionmentioning

confidence: 99%

Effect of pentobarbital anesthesia on ventricular defibrillation threshold in dogs

Babbs

1978

American Heart Journal

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The effect of pentobarbital anesthesia upon the minimal voltage and current required for electrical ventricular defibrillation (the defibrillation threshold) was investigated in dogs. Threshold current, energy, and charge in five dogs averaged 2 per cent, 13 per cent, and 6 per cent less under surgical levels of pentobarbital anesthesia than thresholds in the same animals in the awake, unanesthetized state. In dogs given sufficient pentobarbital to produce apnea and supported by mechanical ventilation, threshold current, energy, and charge averaged 3 per cent, 17 per cent, and 2 per cent less than comparable awake values. These differences were far from statistically significant. In a second study, five dogs were kept for 8 to 10 hours at a surgical level of anesthesia with pentobarbital sodium. Defibrillation threshold current, determined at hourly intervals, did not drift outside ± 10 per cent limits. Arterial blood gas measurements revealed a stable, compensated metabolic acidosis in all animals (pH 7.36 ± 0.06, pCO 2 33 ± 4 mm. Hg, pO 2 71 ± 9 mm. Hg). These data support the validity of defibrillation studies using animals anesthetized with pentobarbital and indicate the stability of the defibrillation threshold under controlled experimental conditions.

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Barbiturate Anesthesia an Abnormal Physiologic Situation

Cited by 22 publications

References 0 publications

Comportamento hemodinâmico e metabólico do choque hemorrágico: estudo experimental no cão

Comportamento hemodinâmico e metabólico do choque hemorrágico: estudo experimental no cão

Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics

Effect of pentobarbital anesthesia on ventricular defibrillation threshold in dogs

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