2024
DOI: 10.3390/ijms25094962
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BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling

Bo Zhao,
Fei An,
Zhenzhen Hao
et al.

Abstract: B cell receptor-associated protein 31 (BAP31) is a transmembrane protein that is widely expressed and primarily located in the endoplasmic reticulum (ER). B cells play a crucial role in the immune system, and BAP31 significantly contributes to the functions of various immune cells. However, the specific role of BAP31 in B lymphocytes development remains unknown. In this study, we utilized a mouse model with BAP31 deleted from B cells to investigate its effects. Our findings reveal a block in early B cell devel… Show more

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