Banxia Baizhu Tianma decoction for hyperlipidemia

Cai, Hongwei; Guo, Yongning; Zhao, Zicong; Chen, Yanhong; Zhao, Song; Chen, Bojun

doi:10.1097/md.0000000000013067

Cited by 6 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Banxia Baizhu Tianma decoction is made up of six Chinese herbal medicines, including Banxia. Research on rats has shown that the Banxia Baizhu Tianma decoction can reduce serum TC, TG, low-density lipoprotein cholesterol, apolipoprotein B, superoxide dismutase, and malondialdehyde in rats with hyperlipidemia [29]. Moreover, Jiang et al found that the Banxia Baizhu Tianma decoction has a significant effect on body weight and TC in mice with obesity-related hypertension, reducing lipid deposition in the roots of arteries, protecting endothelial cells, reducing apoptosis, decreasing the migration rate caused by oxidized low-density lipoproteins, and maintaining cell morphology [30].…”

Section: Discussionmentioning

confidence: 99%

Gualou Xiebai Banxia decoction ameliorates Poloxamer 407-induced hyperlipidemia

Luo

Fan²,

Wang³

et al. 2021

Bioscience Reports

View full text Add to dashboard Cite

Ethnopharmacological relevance: Gualou Xiebai Banxia decoction (GLXBBX) is a well-known traditional Chinese herbal formula that was first discussed in the Synopsis of the Golden Chamber by Zhang Zhongjing in the Eastern Han Dynasty. In traditional Chinese medicine, GLXBBX is commonly prescribed to treat cardiovascular diseases, such as coronary heart disease and atherosclerosis. Objective: The present study aimed to examine GLXBBX’s preventative capacity and elucidate the potential molecular mechanism of Poloxamer 407 (P407)-induced hyperlipidemia in rats. Materials and Methods: Both the control and model groups received pure water, and the test group also received a GLXBBX decoction. For each administration, 3 mL of the solution was administered orally. To establish hyperlipidemia, a solution mixed with 0.25 g/kg P407 dissolved in 0.9% normal saline was injected slowly into the abdominal cavity. At the end of the study, the rats’ plasma lipid levels were calculated using an automatic biochemical analyzer to evaluate the preventative capability of the GLXBBX decoction, and the serum and liver of the rats were collected. Results: The GLXBBX decoction significantly improved P407-induced hyperlipidemia, including increased plasma triglycerides, aspartate aminotransferase elevation, and lipid accumulation. Moreover, GLXBBX decoction treatment increased lipoprotein lipase (LPL) activity and mRNA expression of LPL. Furthermore, GLXBBX significantly suppressed the mRNA expression of stearoyl-CoA desaturase (SCD1). Conclusion: GLXBBX significantly improved P407-induced hyperlipidemia, which may have been related to enhanced LPL activity, increased LPL mRNA expression, and decreased mRNA expression of SCD1.

show abstract

Section: Discussionmentioning

confidence: 99%