This is a study on business bankruptcy analysis and prediction. Traditionally, business bankruptcy prediction study was to build models through different methods and then verify their validity and accuracy with the actual financial information of bankrupt companies. It was still developing over the years. The purpose of this study is to find out the obvious financial ratio that affects the company's bankruptcy, and to give a detailed explanation and analysis, rather than a mathematical equation or a conclusive model. The data was the change in the financial ratios of bankrupt and non-bankrupt companies over time instead of single financial information in the year of bankruptcy. Factor analysis, binary logistic regression, and non-parametric tests were used. By looking for commonalities and priorities in financial ratios, this study speculated on the causes of changes in financial ratios and provided suggestions to managers. The experimental results showed that "Total Assets Related", "Short-term Liabilities Related", "Total Liabilities Related", and "Fixed Assets Related" were significantly different between bankrupt and non-bankrupt companies. After further analysis, the study concluded that sources of financing, the liquidity of the company, and investment were likely to be significant factors that influenced business bankruptcy. The highlight of this study was the more detailed explanation of financial ratio analysis, and its value was the method of avoiding business bankruptcy rather than the judgment of the likelihood of business bankruptcy, as most previous studies have done.