Banded karyotypes of 20 Papionini species reveal no necessary correlation with speciation

Stanyon, Roscoe; Fantini, Claudio; Ciani, Andrea; Chiarelli, B.; Ardito, G.

doi:10.1002/ajp.1350160103

Cited by 27 publications

(22 citation statements)

References 32 publications

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“…On the one hand, a rapid fixation may have been favored by gibbon social structure and ecology, including monogamous matings, nuclear family units, and an arboreal lifestyle. In contrast, the chromosomally conservative Papionini live in large terrestrial groups with multiple male and multiple female matings (28,29). On the other hand, the reduction of fitness due to chromosomal rearrangements may be less drastic than normally proposed.…”

Section: Methodsmentioning

confidence: 92%

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Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.

Jauch

Wienberg

Stanyon

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

282

160

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The homology between hylobatid chromosomes and other primates has long remained elusive. We used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the chromosomes of primates and establish homologies between the human, great ape (chimpanzee, gorilla, and orangutan), and gibbon karyotypes (Hylobates lar species group, 2n = 44). The hybridization patterns unequivocally demonstrate the high degree of chromosomal homology and synteny of great ape and human chromosomes. Relative to human, no translocations were detected in great apes, except for the well-known fusionorigin of human chromosome 2 and a 5;17 translocation in the gorilla. In contrast, numerous translocations were detected that have led to the massive reorganization of the gibbon karyotype: the 22 autosomal human chromosomes have been divided into 51 elements to compose the 21 gibbon autosomes. Molecular cytogenetics promises to rinally allow hylobatids to be integrated into the overall picture of chromosomal evolution in the primates.

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Section: Methodsmentioning

confidence: 92%

“…Papionini karyotypes (macaques, baboons, mandrills, and cercocebus monkeys) are conservative and nearly identical in all these species (29). These karyotypes have frequently been used as an "outgroup" for determining the direction of chromosomal rearrangements in hominoid species.…”

Section: Methodsmentioning

confidence: 99%

Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.

Jauch

Wienberg

Stanyon

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

282

160

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“…The tribe Papionini (F. Cercopithecidae, Catarrhini) includes four genera (Macaca, Mandrillus, Papio and Cercocebus), with highly conserved karyotypes, both in diploid number (2n = 42) and G-banding patterns (Rubio-Goday et al, 1976;Dutrillaux et al, 1979;Brown et al, 1986;Ponsà et al, 1986;Stanyon et al, 1988). The almost complete homology of the banding patterns demonstrated by G-banding comparisons and ZOO-FISH among these species and with the human karyotype (Wienberg et al, 1992;Ruiz-Herrera et al, 2002a) makes the comparison of location of common FSs and ITSs based on G-banding possible.…”

mentioning

confidence: 99%

Evolutionary breakpoints are co-localized with fragile sites and intrachromosomal telomeric sequences in primates

Ruiz‐Herrera¹,

García

Giulotto

et al. 2004

Cytogenet Genome Res

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The concentration of evolutionary breakpoints in primate karyotypes in some particular regions or chromosome bands suggests that these chromosome regions are more prone to breakage. This is the first extensive comparative study which investigates a possible relationship of two genetic markers (intrachromosomal telomeric sequences [TTAGGG]n, [ITSs] and fragile sites [FSs]), which are implicated in the evolutionary process as well as in chromosome rearrangements. For this purpose, we have analyzed: (a) the cytogenetic expression of aphidicolin-induced FSs in Cebus apella and Cebus nigrivittatus (F. Cebidae, Platyrrhini) and Mandrillus sphinx (F. Cercopithecidae, Catarrhini), and (b) the intrachromosomal position of telomeric-like sequences by FISH with a synthetic (TTAGGG)n probe in C. apella chromosomes. The multinomial FSM statistical model allowed us to determinate 53 FSs in C. apella, 16 FSs in C. nigrivittatus and 50 FSs in M. sphinx. As expected, all telomeres hybridized with the probe, and 55 intrachromosomal loci were also detected in the Cebus apella karyotype. The χ² test indicates that the coincidence of the location of Cebus and Mandrillus FSs with the location of human FSs is significant (P < 0.005). Based on a comparative cytogenetic study among different primate species we have identified (or described) the chromosome bands in the karyotypes of Papionini and Cebus species implicated in evolutionary reorganizations. More than 80% of these evolutionary breakpoints are located in chromosome bands that express FSs and/or contain ITSs.

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“…This difference has been taken to phylogenetically ally these taxa, a conclusion supported by limited molecular data [Harris and Disotell, 1998;Page and Goodman, 2001]. A difference in the banding pattern of the Macaca fascicularis chromosome 6 (homologous to human chromosome 5), sometimes interpreted as a paracentric inversion, has never been studied at the molecular level [Stanyon et al, 1988]. Overall, the Papionini illustrate that chromosome rearrangements are not necessarily correlated with speciation due to the fact that over 20 species in this group have conserved essentially identical karyotypes [Stanyon et al, 1988].…”

Section: Papioninimentioning

confidence: 99%

“…However, some intrachromosomal rearrangements or differences found between Papionini species on the basis of banding have never been confirmed at the molecular level [Stanyon et al, 1988]. For instance, differences at the banding level are found most notably in chromosome 9 (homolog to human chromosome 10) of drills, mandrills and mangabeys [Dutrillaux et al, 1982;Stanyon et al, 1983].…”

Section: Papioninimentioning

confidence: 99%

Evolutionary Molecular Cytogenetics of Catarrhine Primates: Past, Present and Future

Stanyon

Rocchi²,

Bigoni³

et al. 2012

Cytogenet Genome Res

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The catarrhine primates were the first group of species studied with comparative molecular cytogenetics. Many of the fundamental techniques and principles of analysis were initially applied to comparisons in these primates, including interspecific chromosome painting, reciprocal chromosome painting and the extensive use of cloned DNA probes for evolutionary analysis. The definition and importance of chromosome syntenies and associations for a correct cladistics analysis of phylogenomic relationships were first applied to catarrhines. These early chromosome painting studies vividly illustrated a striking conservation of the genome between humans and macaques. Contemporarily, it also revealed profound differences between humans and gibbons, a group of species more closely related to humans, making it clear that chromosome evolution did not follow a molecular clock. Chromosome painting has now been applied to more that 60 primate species and the translocation history has been mapped onto the major taxonomic divisions in the tree of primate evolution. In situ hybridization of cloned DNA probes, primarily BAC-FISH, also made it possible to more precisely map breakpoints with spanning and flanking BACs. These studies established marker order and disclosed intrachromosomal rearrangements. When applied comparatively to a range of primate species, they led to the discovery of evolutionary new centromeres as an important new category of chromosome evolution. BAC-FISH studies are intimately connected to genome sequencing, and probes can usually be assigned to a precise location in the genome assembly. This connection ties molecular cytogenetics securely to genome sequencing, assuring that molecular cytogenetics will continue to have a productive future in the multidisciplinary science of phylogenomics.

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Banded karyotypes of 20 Papionini species reveal no necessary correlation with speciation

Cited by 27 publications

References 32 publications

Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.

Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.

Evolutionary breakpoints are co-localized with fragile sites and intrachromosomal telomeric sequences in primates

Evolutionary Molecular Cytogenetics of Catarrhine Primates: Past, Present and Future

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