2011
DOI: 10.1016/j.jmr.2011.06.027
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Band-selective chemical exchange saturation transfer imaging with hyperpolarized xenon-based molecular sensors

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Cited by 25 publications
(25 citation statements)
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“…It has been shown that, compared with CW saturation, pulsed saturation can achieve comparable saturation efficiency at lower power, thus minimizing RF heating. 69 Recently, hyper-CEST data with CB[6] in whole blood was reported using prepulse train with a SAR of 0.025 W/kg, well below the FDA limit of 4 W/kg. 59 …”
Section: Discussionmentioning
confidence: 99%
“…It has been shown that, compared with CW saturation, pulsed saturation can achieve comparable saturation efficiency at lower power, thus minimizing RF heating. 69 Recently, hyper-CEST data with CB[6] in whole blood was reported using prepulse train with a SAR of 0.025 W/kg, well below the FDA limit of 4 W/kg. 59 …”
Section: Discussionmentioning
confidence: 99%
“…The exact field strength allowed is a complicated question, as SAR will also be affected by the choice of transmit coil and use of smaller transmit coils (108) or parallel transmit coils (109) can reduce the deposition of heat. However, in the case that the hardware doesn't allow sufficiently strong cw pulses for saturation, an alternative is to use a train of shaped pulses instead (110), often called pulsed-CEST MRI. A number of waveforms have been tested which were previously used in NMR spectroscopy and conventional MTC studies including: Fermi (96,111), e-burp (67,112), Gaussian (50,113), SEDUCE (110), d-SNOB (110), and Blackman-shaped inversion pulses (114).…”
Section: Introductionmentioning
confidence: 99%
“…Fig. 7 shows two alternative shapes which have been used previously, dSNOB (110) (Fig. 7d-f), and Fermi(96) (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies demonstrated that, compared to a continuous wave, a band-selective saturation sequence based on multiple pulse inversion elements can yield saturation bandwidth tunable over a wide range, while inducing less RF power in the sample and therefore preventing RF tissue heating during imaging. 66 Thus, according to the remarks done in the previous Sections, the quest for a host molecule for which xenon exhibits a strong affinity -and still a high in-out exchange -is made important again. In this sense, so far cryptophanes seem to be the best candidates, as they could provide the higher contrast at low saturation strength.…”
Section: Future Directionsmentioning
confidence: 98%