Band Occlusion of the Atrial Appendage

Slater, A. David; Foley, Jessica L.; Phillips, Lynette; Francischelli, David

doi:10.1111/j.1540-8191.2009.00989.x

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…The band is designed to exert a constant, gentle force onto the underlying tissue to occlude blood flow to the LAA. It has been successfully deployed in complete occlusion of the LAA in 15 of 15 dogs and six of six pigs 42, 43 . A multicenter phase II clinical trial is currently underway in the United States.…”

Section: Novel Nonpharmacologic Approachesmentioning

confidence: 99%

Pharmacologic and Nonpharmacologic Therapies for Stroke Prevention in Nonvalvular Atrial Fibrillation

Han

Cheng

Mathuria

2012

Pacing Clinical Electrophis

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Thromboembolism is the crucial cause of ischemic stroke in patients with atrial fibrillation (AF). Anticoagulation therapy with vitamin K antagonists, such as warfarin, have been proven to be effective for stroke prevention in AF. Nonetheless, the use of warfarin may be limited due to increased risk of bleeding, the potential interaction with multiple foods and drugs, and the need for routine coagulation monitoring. Over the last decade anticoagulants, such as dabigatran and rivaroxaban, have been developed and have shown superiority compared to warfarin for preventing stroke in patients with nonvalvular AF in large randomized trials. In addition, on account of the risk of thrombus formation in the left atrial appendage (LAA), many nonpharmacologic approaches have been developed to reduce stroke risk in patients with AF who are not candidates for anticoagulant therapy. Surgical, epicardial, and endovascular techniques for LAA closure are being investigated currently. Both novel pharmacotherapy and nonpharmacologic approaches for stroke prevention will be detailed in this review.

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Section: Novel Nonpharmacologic Approachesmentioning

confidence: 99%

Pharmacologic and Nonpharmacologic Therapies for Stroke Prevention in Nonvalvular Atrial Fibrillation

Han

Cheng

Mathuria

2012

Pacing Clinical Electrophis

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Cather-Based Approaches to Stroke Prevention in Atrial Fibrillation

Kapur

Mansour

2013

Curr Cardiol Rep

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The left atrial appendage (LAA) is a prominent source of cardioembolic stroke in patients with nonvalvular atrial fibrillation (AF). While systemic anticoagulation is the common therapeutic choice, these medications carry many contraindications and possible complications. Epicardial and endovascular techniques for occlusion of LAA have been explored and early clinical data is accumulating. In the coming years, this data will help guide the management of AF patients at risk of bleeding as well as potentially become first-line therapy to reduce the risk of thromboembolic stroke. The purpose of this article is to review current endovascular and epicardial catheter based LAA occlusion devices and the clinical data supporting their use.

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Left Atrial Appendage Exclusion for Prevention of Stroke in Atrial Fibrillation: Review of Minimally Invasive Approaches

Moss

2014

Curr Cardiol Rep

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Stroke prevention is of vital importance in the management of atrial fibrillation (AF), though the proven strategy of systemic anticoagulation for thromboembolic prophylaxis is underutilized for a variety of reasons. The left atrial appendage (LAA) has long been suspected as the principal source of arterial emboli, particularly in nonvalvular AF, and a variety of techniques for its exclusion from the circulation have been developed. This review highlights the history of the LAA as a target of intervention, and the parallel advances in three minimally invasive strategies for its exclusion: percutaneous occlusion of the LAA orifice from within the left atrium, closed-chest ligation via a percutaneous pericardial approach, and minimally invasive thoracoscopic surgery. While further study is necessary, available evidence suggests that effective LAA exclusion is becoming a viable alternative to anticoagulation for stroke prevention in nonvalvular AF.

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Band Occlusion of the Atrial Appendage

Abstract: Occlusion of a broad-based appendage as seen with human LAA is feasible with this novel band technique.

Cited by 5 publications

References 10 publications

Pharmacologic and Nonpharmacologic Therapies for Stroke Prevention in Nonvalvular Atrial Fibrillation

Pharmacologic and Nonpharmacologic Therapies for Stroke Prevention in Nonvalvular Atrial Fibrillation

Cather-Based Approaches to Stroke Prevention in Atrial Fibrillation

Left Atrial Appendage Exclusion for Prevention of Stroke in Atrial Fibrillation: Review of Minimally Invasive Approaches

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