Bananas as an Energy Source during Exercise: A Metabolomics Approach

Nieman, David C.; Gillitt, Nicholas D.; Henson, Dru A.; Wang, Sha; Shanely, R. Andrew; Knab, Amy M.; Cialdella‐Kam, Lynn; Jin, Fuxia

doi:10.1371/journal.pone.0037479

Cited by 62 publications

(78 citation statements)

References 28 publications

(36 reference statements)

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“…The 75 km cycling time trial was associated with the typical increases in plasma cytokines and granulocyte and monocyte phagocytosis (a marker of post-exercise inflammation) measured during previous trials with carbohydrate-fed athletes [12,40]. Despite significantly higher plasma antioxidant capacity, l -arginine, nitrate, and citrulline, WM ingestion was not associated with alterations in the pattern of change in inflammation and immune measures.…”

Section: Discussionmentioning

confidence: 77%

Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity

et al. 2016

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Consuming carbohydrate- and antioxidant-rich fruits during exercise as a means of supporting and enhancing both performance and health is of interest to endurance athletes. Watermelon (WM) contains carbohydrate, lycopene, l-citrulline, and l-arginine. WM may support exercise performance, augment antioxidant capacity, and act as a countermeasure to exercise-induced inflammation and innate immune changes. Trained cyclists (n = 20, 48 ± 2 years) participated in a randomized, placebo controlled, crossover study. Subjects completed two 75 km cycling time trials after either 2 weeks ingestion of 980 mL/day WM puree or no treatment. Subjects drank either WM puree containing 0.2 gm/kg carbohydrate or a 6% carbohydrate beverage every 15 min during the time trials. Blood samples were taken pre-study and pre-, post-, 1 h post-exercise. WM ingestion versus no treatment for 2-weeks increased plasma l-citrulline and l-arginine concentrations (p < 0.0125). Exercise performance did not differ between WM puree or carbohydrate beverage trials (p > 0.05), however, the rating of perceived exertion was greater during the WM trial (p > 0.05). WM puree versus carbohydrate beverage resulted in a similar pattern of increase in blood glucose, and greater increases in post-exercise plasma antioxidant capacity, l-citrulline, l-arginine, and total nitrate (all p < 0.05), but without differences in systemic markers of inflammation or innate immune function. Daily WM puree consumption fully supported the energy demands of exercise, and increased post-exercise blood levels of WM nutritional components (l-citrulline and l-arginine), antioxidant capacity, and total nitrate, but without an influence on post-exercise inflammation and changes in innate immune function.

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Section: Discussionmentioning

confidence: 77%

Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity

et al. 2016

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“…These early studies helped to refine these techniques for use in exercise research but did not yield any detailed information on specific metabolic responses to exercise (51). Subsequently, metabolomics and proteomics have been used to determine responses to acute exercise (34,42,43,48) and in response to exercise training (49,67). However, we are not aware of any studies that have systematically employed metabolomics to compare metabolic responses to different modes of exercise.…”

mentioning

confidence: 99%

Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise

Peake

Tan

Markworth

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

153

138

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This study investigated the effects of high-intensity interval training (HIIT) vs. work-matched moderate-intensity continuous exercise (MOD) on metabolism and counterregulatory stress hormones. In a randomized and counterbalanced order, 10 well-trained male cyclists and triathletes completed a HIIT session [81.6 Ϯ 3.7% maximum oxygen consumption (V O2 max); 72.0 Ϯ 3.2% peak power output; 792 Ϯ 95 kJ] and a MOD session (66.7 Ϯ 3.5% V O2 max; 48.5 Ϯ 3.1% peak power output; 797 Ϯ 95 kJ). Blood samples were collected before, immediately after, and 1 and 2 h postexercise. Carbohydrate oxidation was higher (P ϭ 0.037; 20%), whereas fat oxidation was lower (P ϭ 0.037; Ϫ47%) during HIIT vs. MOD. Immediately after exercise, plasma glucose (P ϭ 0.024; 20%) and lactate (P Ͻ 0.01; 5.4ϫ) were higher in HIIT vs. MOD, whereas total serum free fatty acid concentration was not significantly different (P ϭ 0.33). Targeted gas chromatography-mass spectromtery metabolomics analysis identified and quantified 49 metabolites in plasma, among which 11 changed after both HIIT and MOD, 13 changed only after HIIT, and 5 changed only after MOD. Notable changes included substantial increases in tricarboxylic acid intermediates and monounsaturated fatty acids after HIIT and marked decreases in amino acids during recovery from both trials. Plasma adrenocorticotrophic hormone (P ϭ 0.019), cortisol (P Ͻ 0.01), and growth hormone (P Ͻ 0.01) were all higher immediately after HIIT. Plasma norepinephrine (P ϭ 0.11) and interleukin-6 (P ϭ 0.20) immediately after exercise were not significantly different between trials. Plasma insulin decreased during recovery from both HIIT and MOD (P Ͻ 0.01). These data indicate distinct differences in specific metabolites and counterregulatory hormones following HIIT vs. MOD and highlight the value of targeted metabolomic analysis to provide more detailed insights into the metabolic demands of exercise. exercise intensity; metabolites; stress hormones; amino acids; free fatty acids; tricarboxylic acid intermediates INTEREST IN HIGH-INTENSITY exercise as an effective mode of exercise training has intensified over the past decade in recognition of three main factors that are commonly cited as limitations to regular physical activity: lack of time, lack of motivation, and chronic diseases that restrict work capacity during exercise (64). This type of training generally consists of relatively brief, intermittent exercise performed either at "allout" effort or at intensities close to maximum oxygen consumption (V O 2 max ) (16). The body of literature supporting the health and fitness benefits of high-intensity interval training (HIIT) is expanding. So too is our knowledge of the molecular mechanisms that accompany adaptations to this form of training (19).Improved metabolism is integral to the benefits of HIIT. Carbohydrate (CHO) oxidation increases with exercise intensity, whereas fat oxidation increases during exercise up to 65-75% V O 2 max and decreases at higher workloads (52, 60). Exercise also stimulates amino ...

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“…Dopamine is formed by Amino acid Tyrosine, a natural compound that can be found in animal product, oat, banana, and grains. Based on the research, Musa cavendishii banana flesh had 2.5-10 mg dopamine [20], other study showed 0,42 mg/100 g dopamine on fleshed banana [21]. Another amino acid is tryptophan, the serotonin precursor.…”

Section: Resultsmentioning

confidence: 98%

“…It is formed from amino acid Tyrosine. Banana has both of the amino acids although they are in small amounts [20]- [21].…”

Section: Introductionmentioning

confidence: 99%

Raja Bandung Banana (Musa paradisiacaL.cv Raja Bandung) Prevents Increased Systolic Blood Pressure in Rats Given Acute Stress Test

Anindyah¹,

Farmawati²

2015

IJPHS

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The relationships between stress and hypertension have been evaluated. Heightened blood pressure (BP) reactions to acute stress have been implicated in cardiovascular disease's development. Consumption of fruit or vegetables lowering BP. This study aimed to evaluate the effect of Raja Bandung Banana (Musa paradisiaca L. cv Raja Bandung) on blood pressure after acute restraint stress and forced swim test.Twenty male Sprague dawley rats were divided into 4 groups (A,B,C,D) and adapted for 3 days. At 4 th day, groups were administered 2 g/200gBw AIN-93M, then exposed to acute restraint (1hour), except group A. After restraint, A&B received water, C received diazepam 0.5mg/kgBW, and D received banana 2.52 g/200gBW. One hour later, the forced swim test was carried out (45 minutes). Blood pressure was measured 1 hour after swim. Result showed, mean of blood pressure significantly increased after treatment (p<0.01) all groups. But, the increasing of blood pressure in C and D group was lower than unrestraint (A) and control (B) group. There was significant difference of blood pressure between control (A&B) and intervention group (C&D), but no significant difference between C and D. This result indicates that Raja Bandung Banana can prevent increased blood pressure on acute stress condition as effective as diazepam.

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Bananas as an Energy Source during Exercise: A Metabolomics Approach

Cited by 62 publications

References 28 publications

Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity

Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity

Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise

Raja Bandung Banana (Musa paradisiacaL.cv Raja Bandung) Prevents Increased Systolic Blood Pressure in Rats Given Acute Stress Test

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