Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice

Chen, Yufeng; Jin, Lu; Li, Yunhong; Xia, Guobin; Chen, Chun; Zhang, Ying

doi:10.1016/j.jff.2018.08.015

Cited by 56 publications

(37 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, quercetin, resveratrol, kaempferol glycosides, and polysaccharide reduced the body weight gain as well as the accumulation of adipose tissue by down-regulating PPARγ and SREBP-1c expression and up-regulating PPARα expression. [6,31]. Our research confirmed that seabuckthorn freeze-dried powder could alleviate obesity-induced abnormal lipid metabolism, and it might be related to abundant bioactive substances like polyphenols, flavonoids, and polysaccharides.…”

Section: Discussionsupporting

confidence: 66%

“…Anti-obesity effects of seabuckthorn freeze-dried powder could result from polyphenols, total sugar, total acid, or dietary fiber [33]. Recent animal studies reported that some plants cramming with bioactive ingredients, such as bamboo-shaving, angelica keiskei, and citrus peel, reduced body weight gain, Lee's index, and ameliorated lipid metabolic disorders by altering the composition and structure of gut microbiota [6,21,34]. On this basis, we further investigated whether the beneficial effect of seabuckthorn freeze-dried powder on the improvement of obesity was associated with the changes of gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, excessive dietary fat intake contributes to high circulation of fat in the bloodstream, and it consequently increases adipose tissue and fat accumulation in the liver, leading to lipid metabolism disorders and obesity [6]. Mounting pieces of evidence have found that gut microbiota plays an important role in the development of obesity [6]. Gut microbiota of humans is a complex and neglected organ, containing at least 10 14 bacteria.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

Guo

Han

et al. 2020

Nutrients

View full text Add to dashboard Cite

This study aimed to investigate the beneficial effects of seabuckthorn freeze-dried powder on high-fat diet-induced obesity and related lipid metabolism disorders, and further explored if this improvement is associated with gut microbiota. Results showed that seabuckthorn freeze-dried powder administration decreased body weight, Lee’s index, adipose tissue weight, liver weight, and serum lipid levels. Moreover, treatment with seabuckthorn freeze-dried powder effectively reduced fat accumulation by modulating the relative expression of genes involved in lipid metabolism through down-regulation of encoding lipogenic and store genes, including SREBP-1c, PPAR-γ, ACC, and SCD1, and up-regulation of regulating genes of fatty acid oxidation, including HSL, CPT-1, and ACOX. Especially, seabuckthorn freeze-dried powder regulated the composition of gut microbiota, such as increasing the ratio of Firmicutes/Bacteroidetes, decreasing relative abundance of harmful bacteria (Desulfovibrio), and increasing relative abundance of beneficial bacteria (Akkermansia and Bacteroides). The changes of beneficial bacteria had a positive correlation with genes encoding lipolysis and a negative correlation with genes encoding lipid lipogenesis and store. The harmful bacteria were just the opposite. Besides, changes in gut microbiota had an obvious effect in the secretion of main metabolites—short-chain fatty acids (SCFAs), especially propionic acid. Thus, our results indicated that the seabuckthorn freeze-dried powder could ameliorate high-fat diet-induced obesity and obesity-associated lipid metabolism disorders by changing the composition and structure of gut microbiota.

show abstract

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

Guo

Han

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Various plant polysaccharides have been certified as effective candidate material for attenuating MetS by improving serum lipid profiles and insulin level in HFD-fed mice (Cao et al, 2019;Chen et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Effect of banana pulp dietary fibers on metabolic syndrome and gut microbiota diversity in high‐fat diet mice

Wei

Yan

et al. 2020

J Food Biochem

View full text Add to dashboard Cite

Banana (Musa nana Lour.) have the effect of anti‐obesity and lipid modulating properties. However, the influences of banana pulp dietary fibers (BP‐DF) on metabolic syndrome (MetS) and gut microbiota (GM) are unknown. In this research, we explore a novel strategy for dietary BP‐DF on attenuation of lipid metabolic disease, GM disorder, and associated mechanisms in high‐fat diet (HFD) mice. BP‐DF can strongly suppress on HFD caused body weight and epididymal fat mass gain, and significantly improved serum lipid profiles, liver lipid profiles, and intestinal function. BP‐DF also significantly improved fecal short‐chain fatty acids formation and fecal ammonia content. BP‐DF impacted the intestinal microorganism at all kinds of taxonomic levels by increasing the proportions of beneficial Lactobacillus, Bacteroidales _S24_7_group, and Alloprevotella and decreasing the disease or obesity associated Sutterella, Streptococcaceae, and Erysipelotrichaceae. The experiments show that BP‐DF may use as a functional ingredient for preventing obesity, MetS, and intestinal microorganism imbalance. Practical applications Obesity result in many metabolic complications, and it poses a great threat to people's health. Nowadays, the introduction of DF may lead to the development of a new strategy in the treatment of obesity and its metabolic syndrome. Our experiments findings show that BP‐DF may use as a functional ingredient for preventing obesity, MetS, and intestinal microorganism imbalance. Therefore, BP‐DF can be applied to the development and production of functional food, and can also be used as an important food functional ingredient, which can be added to various food, such as bread, noodles, baked goods, cakes, etc., to improve its nutritional value.

show abstract

“…HWANG; SUNG, 2001, AKAO et al, 2004, HONG et al 2010VARSHNEY, 2018, KIM et al, 2009. Outros efeitos biológicos, como anti-inflamatório, antidiabético, hepatoprotetor e prebiótico foram relacionados com a presença de polissacarídeos específicos (CHEN et al, 2018, HUANG et al, 2017, DING et al, 1998. A presença de triterpenoides, como fridelina e lupeol (ZHANG et al, 2004) foi associada com a atividade antitumoral e o efeito antifadiga observado in vivo em ratos (LU et al, 2010, ZHANG et al, 2006, enquanto a ação antimicrobiana, antifúngica e antiparasitária foi justificada pela presença de derivados de benzoquinona (NISHINA and UCHIBORI, 1991) também dão o começo para as cadeias de ácidos graxos tais como ácido palmítico (C16H32O2) e alguns ácidos fenólicos simples pela reação de ciclização e enolização.…”

unclassified

Atividade antioxidante e fotoprotetora de bambus nativos do Sudeste brasileiro

Wróblewska¹

View full text Add to dashboard Cite

Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice

Cited by 56 publications

References 41 publications

Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

Effect of banana pulp dietary fibers on metabolic syndrome and gut microbiota diversity in high‐fat diet mice

Atividade antioxidante e fotoprotetora de bambus nativos do Sudeste brasileiro

Contact Info

Product

Resources

About