Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea

Shi, Daning; Xi, Xinping; Wang, Lei; Gao, Yitian; Ma, Chengbang; Chen, Hang; Chen, Tianbao; Shaw, Christopher

doi:10.3390/toxins8070213

Cited by 3 publications

(3 citation statements)

References 23 publications

(63 reference statements)

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“…The skin secretions of amphibians continue to be an excellent source for the discovery of novel peptides [ 8 , 9 ]. The pharmacological effects of a novel amidated octapeptide, named WL-8, which was isolated from the skin secretions of the African running frog, Kassina senegalensis , were determined on smooth muscle preparations and the peptide was found to be a potent relaxant of vascular smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis

Wang

et al. 2017

Molecules

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The defensive skin secretions of amphibians continue to be an excellent source of novel biologically-active peptides. Here we report the identification and pharmacological activity of a novel C-terminally amided myotropic octapeptide from the skin secretion of the African hyperoliid frog, Kassina senegalensis. The 8-amino acid peptide has the following primary structure: WMSLGWSL-amide and has a molecular mass of 978 Da. The primary structure and organisation of the biosynthetic precursor of WL-8 amide was successfully deduced from cloned skin secretion-derived cDNA. The open-reading frame encoded a single copy of WL-8, located at the C-terminus. Synthetic WL-8 amide was found to cause relaxation of rat tail artery smooth muscle with an EC50 of 25.98 nM. This peptide is unique in terms of its primary structure and is unlike any other peptide previously isolated from an amphibian source which has been archived in the NCBI database. WL-8 amide thus represents the prototype of a novel family of myotropic peptide from amphibian defensive skin secretions.

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Section: Discussionmentioning

confidence: 99%

Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis

Wang

et al. 2017

Molecules

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“…The skin is one of the most stress‐exposed body tissues and requires certain mechanisms to cope with such pressure. 1 , 2 Amphibians’ skin presents an arsenal of original bioactive compounds 3 that allows adaptation to environments with extreme features, such as high oxygen levels, 4 low temperature and high ultraviolet (UV) radiation. Additionally, the skin secretion of most amphibians is composed by molecules that act in a variety of defence mechanisms against external aggressors, such as microorganisms, parasites or predators.…”

Section: Introductionmentioning

confidence: 99%

“…The skin is one of the most stress-exposed body tissues and requires certain mechanisms to cope with such pressure. 1,2 Amphibians' skin presents an arsenal of original bioactive compounds 3 that allows adaptation to environments with extreme features, such as high oxygen levels, 4 low temperature and high ultraviolet (UV) radiation.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi

Plácido

Amaral

Teixeira

et al. 2022

J Cellular Molecular Medi

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Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian's skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fractionated using RP-HPLC.De novo peptide sequencing was conducted using MALDI MS/MS. The primary structure of PpT-2 (FPWLLS-NH 2 ) was confirmed by Edman degradation and subsequently

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Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns

Lam

Lee

Wong

et al. 2017

Critical Reviews in Microbiology

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Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topical antimicrobial therapy emerges as an attractive route for the treatment of infectious diseases. The topical antimicrobial therapy is based on the absorption of high drug doses in a readily accessible skin surface, resulting in a reduction of microbial proliferation at infected skin sites. Topical antimicrobials retain the following features: (a) they are able to escape the enzymatic degradation and rapid clearance in the gastrointestinal tract or the first-pass metabolism during oral administration; (b) alleviate the physical discomfort related to intravenous injection; (c) reduce possible adverse effects and drug interactions of systemic administrations; (d) increase patient compliance and convenience; and (e) reduce the treatment costs. Novel antimicrobials for topical application have been widely exploited to control the emergence of drug-resistant microorganisms. This review provides a description of antimicrobial resistance, common microorganisms causing skin and soft tissue infections, topical delivery route of antimicrobials, safety concerns of topical antimicrobials, recent advances, challenges and future prospective in topical antimicrobial development.

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Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea

Cited by 3 publications

References 23 publications

Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis

Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis

Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi

Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns

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