Balo's concentric sclerosis associated with primary human herpesvirus 6 infection

A 17-Year-Old Girl With Acute Onset of Hemiparesis

“…A case report suggests that a late primary infection with human herpesvirus 6 may be associated with BCS. 8 The disease was historically diagnosed postmortem, with autopsy revealing brain lesions with the characteristic pattern of concentric rings of demyelination. 9 Characteristic findings on MRI include concentric rings or a whorled appearance on T2-weighted images and contrast-enhanced T1-weighted images, which have been observed in the spinal cord, cerebellum, brainstem, optic chiasm, and cerebral hemispheres.…”

Концентричний Склероз Бало: Науковий Огляд І особисте Спостереження

“…Описаны случаи КСБ, начинающиеся с гемианопсии и изоли-рованной амнестической афазии [6], а также единич-ные наблюдения бессимптомного течения концен-трического склероза Бало, выявленные при аутопсии. Несмотря на изначально большую зону поражения, общемозговые симптомы, как правило, появляются на поздних стадиях заболевания.…”

Baló’s Encephalitis Periaxialis Concentrica

“…A recent example reported was associated with primary human herpesvirus 6 infection [5]. The active concentric lesions follow a patternof demyelination that resembles the tissue injury of hypoxia.…”

“…Patients reported with familial Schilder’s disease are probably instances of sudanophilic cerebral sclerosis, Krabbe disease or metachromatic leucoencephalopathy. Though phenotypic variations are common, the variant reported by Jozsef Baló [4] is remarkable and there is still uncertainty about whether his case represented a type of Marburg’s acute multiple sclerosis or a variant of Schilder’s disease [5]. Marburg, in a prescient paper described an acute illness, which terminated life within 1 year.…”