Balloon Cell Primary Nodular Melanoma: Dermatoscopy Evidences

Resende, Fernanda Simões Seabra; Conforti, Claudio; Giuffrida, Roberta; Corneli, Paola; Fagotti, Serena; Custrin, Ana; Shafiei, Venus; Zalaudek, Iris; Meo, Nicola di

doi:10.5826/dpc.0902a15

Cited by 6 publications

(6 citation statements)

References 2 publications

(1 reference statement)

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“…Over the years, there have been different reports of BCM since Gardner’s first report in 1970 [ 9 ], which reported a case of BCM developed at the level of the back of an older patient. Since then, descriptions of this entity have multiplied [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , ...…”

Section: Discussionmentioning

confidence: 99%

“…As described in the literature, even in our presented cases, there were no distinctive clinical characteristics, being generally present the suspicion of MM. In this regard, in recent years, some authors [ 57 ] have tried to look for suggestive and distinctive dermaoscopic criteria for the diagnosis of BCM. Resente F. et al, for example, have found that elements such as yellowish structureless areas, white lines, irregular hairpin-shaped and curved vessels can be suggestive of BCM.…”

Section: Discussionmentioning

confidence: 99%

“…We also remember entities such as clear-cell syringoma, granular cell tumor, malignant eccrine acrospiroma, sebaceous carcinoma, atypical fibroxanthoma and lepromatous leprosy. In all these cases, immunohistochemical investigations and essential integration with clinical-anamnestic information may help in the correct nosographic classification [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

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Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature

et al. 2022

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Background: balloon cell melanoma represents less than 1% of all histological forms of malignant melanoma and represents a diagnostic challenge for the dermatopathologist. Methods: in this paper we present our cases of BCM found in our daily practice from 1 January 2008 to 31 December 2021, and we conduct a review of the literature relating to this entity in the period from the first description, 1970, to early 2022. Results: four cases of melanoma balloon cell have been extrapolated from our electronic database, while in the review of the literature we have identified 115 cases of patients with primary and/or metastatic BCM. Conclusions: we believe that future studies with numerous case series are essential not only to increase the knowledge of the pathophysiology of this neoplasm but also to correctly evaluate the response of BCM patients to new oncological therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature

et al. 2022

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“…Disturbing skin lesions should be viewed by a dermatologist through dermatoscopy, which increases diagnostic accuracy, allowing for early detection of melanoma. Importantly, it is also a noninvasive examination and can be safely performed in pregnant women 15,46–52 . Changes in specific dermatoscopic and clinical features within a nevus should lead to an excisional biopsy with adequate margins and subsequent histopathologic examination 53 .…”

Section: Methodsmentioning

confidence: 99%

Melanoma During Pregnancy as a Complicated Medical Problem

Kościelecka¹,

Kubik-Machura²,

Kuć³

et al. 2023

Obstetrical &Amp; Gynecological Survey

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ImportancePregnancy-associated melanomas (PAMs)—this is how melanomas identified during the childbearing years or up to 1 year after birth have been defined, accounting for one third of women in whom it is diagnosed. The exact epidemiology of melanoma is difficult to determine. However, its incidence is undoubtedly increasing, most likely related to the increasing age of mothers.ObjectiveThe purpose of this study was to review the prognosis, diagnosis, and treatment; the effect of melanoma on pregnancy; and the effect of pregnancy on melanoma and melanocytic lesions.Evidence AcquisitionAn extensive manual search of major electronic databases was conducted in January 2022. The following literature review provides comprehensive coverage of PAMs.ResultsAny new nevus detected during pregnancy and changes in the nevus regarding color, diameter, symmetry, or lesion border require medical evaluation. New therapies for malignant melanoma, such as immunotherapy and targeted therapy, have improved overall survival and progression-free survival, but their use is often contraindicated in pregnant patients. Melanoma is considered to be the neoplasm most commonly involving the fetus and placenta.ConclusionsThere are reports where immunotherapy and targeted therapy used in the patient were not associated with serious consequences for the fetus, being a therapeutic option for the patient. The described cases of pregnancy outcome during modern melanoma treatment are extremely important and may allow to shape the optimal therapeutic regimen in pregnant women with melanoma.RelevanceEducation of pregnant women in the context of observation of skin lesions as well as maintenance of oncological vigilance by physicians seem to be an important element in limiting difficult decisions related to therapy of more advanced disease. Further large-scale studies using modern treatment in pregnant women with melanoma are needed.Target AudienceObstetricians and gynecologists, family physicians.Learning ObjectivesAfter completing this activity, the learner should be better able to describe the importance of oncologic vigilance in the context of developing melanoma in a pregnant woman; discuss the need for further research on the use of immunotherapy and targeted therapy in pregnant women with melanoma; and explain the need for oncologic vigilance in the context of melanoma in children of mothers who developed melanoma during pregnancy.

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“…Apparently, histopathologic diagnosis of BCM is more challenging considering morphologic similarity of cells in both BCM and BCN. The presence of cytological atypia, greater nuclear pleomorphism, higher Ki 67 mitotic index, and a lack of maturation of melanocyte towards the base of the lesion should help in differentiating those lesions from BCN (2,11).…”

mentioning

confidence: 99%

Balloon Cell Nevus – Report of Three Cases

Jović

Popović

Cekić

et al. 2019

Serbian Journal of Dermatology and Venereology

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The balloon cell nevus is a rare and unusual benign melanocytic lesion characterized histologically by complete or predominant presence of balloon-cell transformed melanocytes. They represent approximately 1.7% of all melanocytic nevi. Three female patients, aged 30, 14 and 7 years, with lesions located on the back and head are included in the presented report. The dermoscopic examination revealed the repetitive dermoscopic features in all three patients: white and yellowish aggregated globules. In conclusion, balloon cell nevi are clinically indistinguishable from the common nevi. Dermoscopy can be useful in their recognition since balloon cell nevi exhibit some distinct dermoscopic features in a form of aggregated white and/or yellow globules.

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Balloon Cell Primary Nodular Melanoma: Dermatoscopy Evidences

Cited by 6 publications

References 2 publications

Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature

Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature

Melanoma During Pregnancy as a Complicated Medical Problem

Balloon Cell Nevus – Report of Three Cases

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