Ball Milling Synthesis of Silica Nanoparticle from Rice Husk Ash for Drug Delivery Application

Abstract

Silica nanoparticles were synthesized from rice husk ash at room temperature by using high energy planetary ball mill. The milling time and mill rotational speed were varied in four levels. The morphology of the synthesized powders was investigated by the FE-SEM and TEM image as well as XRD patterns. The results have revealed that the nano-sized amorphous silica particles are formed after about 6 h ball milling and they are spherical in shape. The average particle size of the silica powders is found to be around 70 nm which decreases with increasing ball milling time or mill rotational speed. The as-synthesized silica nanoparticles were subsequently employed as drug carrier to investigate in vitro release behavior of Penicillin-G in simulated body fluid. UV-Vis spectroscopy was used to determine the amount of Penicillin-G released from the carrier. Penicillin-G release profile from silica nanoparticles exhibited a delayed release effect.

Nonlinear Effects of Nanoparticles: Biological Variability from Hormetic Doses, Small Particle Sizes, and Dynamic Adaptive Interactions

“…For more general sustainable NP manufacturing, natural plant materials such as English ivy, certain native plants from India, the traditional Chinese herb Cuscuta chinensis, glycyrrhizic acid from radix glycyrrhizae, guar gum, and rice husk also can also release their own organic nanoparticles of various sizes under appropriate conditions (Barve and Chaughule, 2013; Burris et al, 2012;Im et al, 2011;Lenaghan et al, 2013;Salavati-Niasari et al, 2012;Soumya et al, 2010;Wang et al, 2013;Yen et al, 2008). Beyond plant sources, a combination of ball-milling and ultrasound can reduce other organic material sources such as waste eggshells into calcium carbonate nanoparticles (Hassan et al, 2013).…”

Biomass as a sustainable resource for value‐added modern materials: a review

“…Porous silica nanoparticles with a diameter of ~70–75 nm was synthesized using ball‐milling method. Diameter size depends upon the rotational speed and milling times.This showed that a nanoporous silica carrier delayed the release of penicillin G. This can be beneficial for the controlled release of drugs 261. Amorphous silica‐based porous bioactive ceramics were prepared successfully by a gel‐casting method using silica xerogels powder derived from RHA.…”

Enhancement of adaptive biological effects by nanotechnology preparation methods in homeopathic medicines

“…85 Nanotechnologists have reported that ball milling generates NPs from rice husk ash. 81 Ball milling of eggshells, combined with ultrasound, makes calcium carbonate nanoparticles (cf., Calcarea Carbonica) Figure 1 Relationship between synthetic identity, biological identity, and physiological response. Synthetic identity is the size, shape, and surface chemistry of a nanomaterial post-synthesis.…”

“…79 These nanotechnology processes are respectively analogous to homeopathic manual trituration in dry lactose or succussions in liquid solutions. 79,81,86 One nanotechnology group found that combining milling with ultrasound agitation of the solutions was most effective for creating and dispersing the resultant NPs compared with either method by itself. 87 Clearly the traditional methods of homeopathic manufacturing with triturating and succussing are not identical to the procedures of modern nanotechnology, but the mechanical processes of prolonged grinding and agitation in solution overlap.…”