Cogito ergo sum" ("I think therefore I am") 1 Rene Descartes, 1596-1650 "The important thing is not to stop questioning. Curiosity has its own reason for existing." 2 Albert, Einstein, 1879-1955 "The only person who is educated is the one who has learned how to learn and change." 3 Carl Rogers, 1902-1987 Life is full of challenges-ups and downs-triumph and tragedy across typically a multi-decade journey. Some problems are small and easy to solve (e.g., "What should I eat for breakfast today?"). Other problems are more complex and vexing-challenges that are not so easily met (e.g., "How am I to cope with this tragic situation in such a way that growth, development, and well-being are likely to result, rather than anxiety, sadness, or the loss of hope?"). Based on the above quotes, Descartes, Einstein, and Rogers seem to suggest that curiosity, reason, and learning are essential to successful coping with complex, vexing, or sometimes overwhelming problems. The content of issue 57(4) of the International Journal of Psychiatry in Medicine (IJPM) presents a grouping of articles that represents how diverse groups may choose to address challenging problems in a constructive, growth-oriented manner.The content of this issue of IJPM contains two broad groupings of ten total articles for the reader's consideration. The first six readings are based on the ideas of Michael