Balancing the Scales: The Dual Role of Interleukins in Bone Metastatic Microenvironments
Ahmad Dawalibi,
Amal Ahmed Alosaimi,
Khalid S. Mohammad
Abstract:Bone metastases, a common and debilitating consequence of advanced cancers, involve a complex interplay between malignant cells and the bone microenvironment. Central to this interaction are interleukins (ILs), a group of cytokines with critical roles in immune modulation and inflammation. This review explores the dualistic nature of pro-inflammatory and anti-inflammatory interleukins in bone metastases, emphasizing their molecular mechanisms, pathological impacts, and therapeutic potential. Pro-inflammatory i… Show more
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