Balancing the efficacy and toxicity of chemotherapy in colorectal cancer

Braun, Michael; Seymour, Michel

doi:10.1177/1758834010388342

Cited by 98 publications

(73 citation statements)

References 48 publications

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“…An important aim of adjunct treatment in oncology patients is decreasing chemotherapy toxicity, since side effects lead to increased intervals between chemotherapy cycles or require dose reduction, and these changes have a negative effect on treatment results (6). The options for treating such disorders remain limited (7,8).…”

Section: Introductionmentioning

confidence: 99%

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Panchenko

Fedoros

Pigarev³

et al. 2018

Exp Ther Med

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Abstract. BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic acid and retinol, and possesses geroprotective activity. The present study examined the effect of BP-C3 (80 mg/kg, administered 18 times in total by gavage) on the development of haematological and intestinal manifestations of toxicity following 5-fluorouracil (5-FU; 150 mg/kg, administered once via intravenous injection) administration in outbred male Swiss-H Rappolovo (SHR) mice. The use of BP-C3 on therapeutic and preventative/therapeutic schedules demonstrated that it was protective against the toxic effect of 5-FU exerted on the lymphopoietic organs. Administering ВР-С3 24 h after 5-FU (therapeutic schedule) had an effect on the recovery of leukopoiesis and prevented anaemia in the mice. In the mice that received 5-FU and 5-FU with BP-C3 prior to and following administration of the chemotherapeutic agent (preventative/therapeutic schedule), mild anaemia developed by day 7. Administration of BP-C3 without 5-FU did not affect blood cell differentiation in the mice. Thus, BP-C3, depending on the administration schedule, had different effects on the haematological parameters of haematopoietic organs and peripheral blood in mice exposed to 5-FU. BP-C3 promoted intestinal crypt survival when administered on the preventative/therapeutic and therapeutic schedules, suggesting that the formulation protects the epithelium of the small intestine against damage by 5-FU.

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Section: Introductionmentioning

confidence: 99%

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Panchenko

Fedoros

Pigarev³

et al. 2018

Exp Ther Med

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“…Thus, the new concept of combined chemoprevention by multiple agents or by the consumption of "whole foods" has become an increasingly attractive area of study (Mehta et al, 2010). Several reports have described the ability of these naturally derived compounds to modulate the process of carcinogenesis; either by blocking or reversing, with nominal cytotoxicity (Braun and Seymour, 2011;Lee et al, 2011). For example the use of natural compounds in combination with 5-FU may provide effective colorectal cancer treatment by enhancing tumoricidal activity while reducing dose-related toxicity and resistance.…”

Section: Introductionmentioning

confidence: 99%

“…However, despite remarkable progress in these approaches, effective therapeutic outcome is minimal owing to the incomplete eradication of the disease and unfavorable side effects, which regularly impede effective treatment (Braun and Seymour, 2011). 5-Fluorouracil (5-FU) is one of the most commonly used therapeutic agents in first-line therapy against colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

Hakim¹,

Alias²,

Makpol³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…7,8 A seleção do tratamento deve considerar as características fisiológicas e a capacidade funcional de cada paciente, perfil de toxicidade, preferências do doente e protocolos terapêuticos institucionais. 9 Em que pese os benefícios clínicos alcança-dos com o uso da quimioterapia, é importante destacar que os medicamentos empregados no tratamento do CCR podem provocar várias toxicidades nos pacientes 10 . Estas toxicidades podem estar relacionadas ao tratamento ou serem consideradas reações adversas aos medicamentos (RAM), entendida como uma "reação nociva e não intencional que ocorre em doses normalmente usadas no homem para profilaxia, diagnóstico, terapia da doença ou para a modificação de funções fisiológicas" (p.40).…”

Section: Introductionunclassified

Adverse drug reaction: a comparative analysis of protocols used for treatment of colorectal cancer

Melo¹,

Cardoso²,

Silva³

2017

Medicina (Ribeirão Preto)

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Modelo do estudo: Estudo de coorte. Objetivo: Analisar as reações adversas ocorridas em pacientes brasileiros com câncer colorretal submetidos ao tratamento quimioterápico com dois protocolos distintos, visando identificar os tipos e a severidade das alterações mais frequentes. Método: Foram avaliados 63 pacientes, que iniciaram tratamento entre junho de 2014 a maio de 2015 em uma instituição do Rio de Janeiro, subdivididos em dois grupos: protocolo mFOLFOX6 (esquema contendo oxaliplatina 85mg/m2, ácido folínico 400mg/m2 e 5-fluorouracil em infusão em bolus 400mg/m2 e contínua 2.400mg/ m2, n= 40) e protocolo FOLFIRI (esquema contendo irinotecano 180mg/m2, ácido folínico 400mg/m2 e 5-fluorouracil em infusão em bolus 400mg/m2 e contínua 2.400mg/m2, n= 23). Foram coletados do prontuário dados relacionados ao perfil demográfico e clínico dos pacientes, além de informações do tratamento realizado e das toxicidades manifestadas. As toxicidades foram classificadas quanto à gravidade (graus 1, 2, 3 e 4) e causalidade (definida, provável, possível e duvidosa). Resultados: Foi observada alta frequência de toxicidades em ambos os grupos, atingindo 92,5% dos pacientes com protocolo mFOLFOX6 e 95,6% com protocolo FOLFIRI. As toxicidades gastrointestinais e neurológicas foram as mais frequentes, independente do grupo. Ao comparar a ocorrência das reações intergrupos, houve diferença apenas para as toxicidades gastrointestinais (p=0,035). Em 17,5% dos pacientes do grupo mFOLFOX6 (n= 7) e em 8,7% do grupo FOLFIRI (n= 2) se observou toxicidades dos tipos 3 e 4, sendo estas classificadas como provável reação adversa aos medicamentos. Conclusão: As toxicidades foram mais variadas e frequentes no grupo mFOLFOX6 em comparação ao grupo FOLFIRI. Entretanto, não se observou diferença na severidade e na causalidade das reações ocorridas em ambos os grupos.

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Balancing the efficacy and toxicity of chemotherapy in colorectal cancer

Cited by 98 publications

References 48 publications

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells

Adverse drug reaction: a comparative analysis of protocols used for treatment of colorectal cancer

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