Balancing the AspC and AspA Pathways of Escherichia coli by Systematic Metabolic Engineering Strategy for High-Efficient l-Homoserine Production
Yuanyuan Chen,
Lianggang Huang,
Tao Yu
et al.
Abstract:L-Homoserine is a promising C4 platform compound used in the agricultural, cosmetic, and pharmaceutical industries. Numerous works have been conducted to engineer Escherichia coli to be an excellent L-homoserine producer, but it is still unable to meet the industrial-scale demand. Herein, we successfully engineered a plasmid-free and noninducible E. coli strain with highly efficient L-homoserine production through balancing AspC and AspA synthesis pathways. First, an initial strain was constructed by increasin… Show more
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