2012
DOI: 10.1371/journal.pgen.1002813
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Balancing Selection at the Tomato RCR3 Guardee Gene Family Maintains Variation in Strength of Pathogen Defense

Abstract: Coevolution between hosts and pathogens is thought to occur between interacting molecules of both species. This results in the maintenance of genetic diversity at pathogen antigens (or so-called effectors) and host resistance genes such as the major histocompatibility complex (MHC) in mammals or resistance (R) genes in plants. In plant–pathogen interactions, the current paradigm posits that a specific defense response is activated upon recognition of pathogen effectors via interaction with their corresponding … Show more

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Cited by 67 publications
(72 citation statements)
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“…This probe was subsequently used to monitor PLCP activities during immunity and senescence (Martínez et al, 2007a;Shabab et al, 2008), to study protease activation (Gilroy et al, 2007;Wang et al, 2008;Gu et al, 2012), and to reveal the selectivity of endogenous and pathogen-derived protease inhibitors (Rooney et al, 2005;Tian et al, 2007;Shabab et al, 2008;van Esse et al, 2008;Song et al, 2009;Kaschani et al, 2010;Lampl et al, 2010;Hörger et al, 2012;Lozano-Torres et al, 2012;van der Linde et al, 2012;Mueller et al, 2013;Dong et al, 2014). Although powerful, a disadvantage of DCG-04 profiling is that this biotinylated probe involves an indirect detection using streptavidin-horseradish peroxidase, which reduces throughput and resolution.…”
mentioning
confidence: 99%
“…This probe was subsequently used to monitor PLCP activities during immunity and senescence (Martínez et al, 2007a;Shabab et al, 2008), to study protease activation (Gilroy et al, 2007;Wang et al, 2008;Gu et al, 2012), and to reveal the selectivity of endogenous and pathogen-derived protease inhibitors (Rooney et al, 2005;Tian et al, 2007;Shabab et al, 2008;van Esse et al, 2008;Song et al, 2009;Kaschani et al, 2010;Lampl et al, 2010;Hörger et al, 2012;Lozano-Torres et al, 2012;van der Linde et al, 2012;Mueller et al, 2013;Dong et al, 2014). Although powerful, a disadvantage of DCG-04 profiling is that this biotinylated probe involves an indirect detection using streptavidin-horseradish peroxidase, which reduces throughput and resolution.…”
mentioning
confidence: 99%
“…Indeed, unrelated effector proteins (Avr2, EpiCs, and Vap1) target secreted tomato proteases [2,19,29]. This process is associated with the accumulation of variant residues on the surface of Rcr3 and Pip1, some of which affect inhibitor affinity [3,[29][30][31]. Next, gene duplication and diversification of the duplicates occurred, probably driven by the arms race with pathogenderived inhibitors ( Figure 4C).…”
Section: Pip1 Is a Major Immune Protease Against Various Apoplastic Pmentioning
confidence: 99%
“…These attacks can lead to strong selective forces on the plant genome in wild ecosystems and can cause significant financial and yield losses in agricultural crops (Bergelson et al, 2001; Van der Hoorn et al, 2002;Mauricio et al, 2003;Rose et al, 2007;Fisher et al, 2012;Hörger et al, 2012;Züst et al, 2012;Karasov et al, 2014). In turn, pathogens have evolved an array of virulence mechanisms based on their infection strategy that causes a prolonged selection pressure on plants to evolve complex and coherent innate immune systems.…”
Section: Introductionmentioning
confidence: 99%