Balancing power density based quantum yield characterization of upconverting nanoparticles for arbitrary excitation intensities

Liu, Haichun; Xu, Cuilian; Lindgren, David; Xie, Hai‐Yan; Thomas, Diana; Gundlach, Carsten; Andersson‐Engels, Stefan

doi:10.1039/c3nr00469d

Cited by 95 publications

(107 citation statements)

References 44 publications

(62 reference statements)

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“…This can be explained by the fact that the balancing power density of UCNPs is highly dependent on C 1 . 30 Above this power density, the UCNPs would behave more linearly in emitting upconverted photons upon NIR excitation, 30 leading to decreased signal gain by using pulsed excitation.…”

Section: Numerical Simulations On the Qy Increase By The Pulsed Excitmentioning

confidence: 99%

“…The power density dependent steady-state QY of the used UCNPs have been measured and reported recently in our previous work. 30 The ETU rates were thus selected on the principle of giving the best fitting of the simulated power density dependency of steady-state QY with the measured results (see the ESI for the selection of the ETU rates). Table 1 summarizes the pa-rameter values used in the simulations.…”

Section: Numerical Simulations On the Qy Increase By The Pulsed Excitmentioning

confidence: 99%

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confidence: 99%

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Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Liu

Dumlupinar

et al. 2013

Nanoscale

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-Engels, S. (2013). Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power. Nanoscale, 5(20), 10034-10040. https://doi.org/10.1039/c3nr01917aRegistered Charity Number 207890 Accepted ManuscriptThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, which is prior to technical editing, formatting and proof reading. This free service from RSC Publishing allows authors to make their results available to the community, in citable form, before publication of the edited article. This Accepted Manuscript will be replaced by the edited and formatted Advance Article as soon as this is available.To cite this manuscript please use its permanent Digital Object Identifier (DOI®), which is identical for all formats of publication.More information about Accepted Manuscripts can be found in the Information for Authors.Please note that technical editing may introduce minor changes to the text and/or graphics contained in the manuscript submitted by the author(s) which may alter content, and that the standard Terms & Conditions and the ethical guidelines that apply to the journal are still applicable. In no event shall the RSC be held responsible for any errors or omissions in these Accepted Manuscript manuscripts or any consequences arising from the use of any information contained in them. We have accomplished deep tissue optical imaging of upconverting nanoparticles at 800 nm, using millisecond single pulse excitation with high peak power. This is achieved by carefully choosing the pulse parameters, derived from time-resolved rateequation analysis, which result in higher intrinsic quantum yield that is utilized by upconverting nanoparticles for generating this near infrared upconversion emission. The pulsed excitation approach thus promises previously unreachable imaging depths and shorter data acquisition times compared with continuous wave excitation, while simultaneously keeping the possible thermal side-effects of the excitation light moderate. These key results facilitate means to break through the general shallow depth limit of upconverting-nanoparticle-based fluorescence techniques, necessary for a range of biomedical applications, including diffuse optical imaging, photodynamic therapy and remote activation of biomolecules in deep tissues. www.rsc.org/nanoscale

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Section: Numerical Simulations On the Qy Increase By The Pulsed Excitmentioning

confidence: 99%

Section: Numerical Simulations On the Qy Increase By The Pulsed Excitmentioning

confidence: 99%

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Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Liu

Dumlupinar

et al. 2013

Nanoscale

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“…Experimental QY data measured on core NaYF 4 :Yb 3+ ,Tm 3+ and core-shell NaYF 4 :Yb 3+ ,Tm 3+ @NaYF 4 UCNPs can be well fitted through Eq. 2, as shown in Fig.…”

Section: Quantum Yield Characterization Of Yb 3+ Sensitized Two-photomentioning

confidence: 99%

“…It can be seen from the above set of equations that the QY of the two-photon UC emission can be described by [4],…”

Section: Quantum Yield Characterization Of Yb 3+ Sensitized Two-photomentioning

confidence: 99%

Quantum yield characterization and excitation scheme optimization of upconverting nanoparticles

Liu

Jensen

et al. 2014

Biomedical Optics 2014

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Near‐Infrared Fluorescent Nanomaterials for Bioimaging and Sensing

Reineck

Gibson

2016

Advanced Optical Materials

138

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A great challenge in noninvasive biomedical imaging is the acquisition of images inside a biological system at the cellular level. Common modalities used today such as magnetic resonance or computed tomography imaging have the advantage that any part of a living organism can be imaged at any depth, but are limited to millimeter resolution and can usually not be employed e.g., for surgical guidance. Optical imaging techniques offer resolution on the 100 nanometer scale, but are limited by the strong attenuation of visible light by biological matter and are traditionally used to image on the surface. Near‐infrared light in the “biological windows” can penetrate much deeper into biological samples, rendering fluorescence‐based imaging a viable alternative. In the past two decades, many fluorescent nanomaterials have been developed to operate in the near infrared, yet only few materials emitting above 1000 nm exist and none are approved for clinical use. This review describes recent advances in the development and use of near‐infrared fluorescent nanomaterials for biomedical imaging and sensing applications. The physical and chemical properties as well as the bioconjugation and application of materials such as organic fluorophores, semiconductor quantum dots, carbon‐based materials, rare earth materials, and polymer particles are discussed.

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Balancing power density based quantum yield characterization of upconverting nanoparticles for arbitrary excitation intensities

Cited by 95 publications

References 44 publications

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Quantum yield characterization and excitation scheme optimization of upconverting nanoparticles

Near‐Infrared Fluorescent Nanomaterials for Bioimaging and Sensing

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