Balancing mechanical strength with bioactivity in chitosan–calcium phosphate 3D microsphere scaffolds for bone tissue engineering: air- vs. freeze-drying processes

Nguyen, Duong Thanh; McCanless, Jonathan D.; Mecwan, Marvin; Noblett, A. P.; Haggard, Warren O.; Smith, Richard A.; Bumgardner, Joel D.

doi:10.1080/09205063.2012.735099

Cited by 25 publications

(19 citation statements)

References 22 publications

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“…Air drying of this scaffold enhances its bioactivity. Given its optimum strength, degradation resistance, and cell-supportive characteristics, chitosan can be used for bone tissue engineering [86]. …”

Section: Structure and Properties Of Grafts And Bone Substitutesmentioning

confidence: 99%

Bone regenerative medicine: classic options, novel strategies, and future directions

et al. 2014

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This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.

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Section: Structure and Properties Of Grafts And Bone Substitutesmentioning

confidence: 99%

Bone regenerative medicine: classic options, novel strategies, and future directions

et al. 2014

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“…Just like randomly combining HAp and collagen is no guarantee that a composite structure as stable and sturdy as bone will be produced, so does it frequently occur that two composites formed from identical components, but by slightly different means, yield drastically different end results. Such was the case with chitosan-HAp scaffolds whereby the air-dried ones demonstrated a threefold increase in compressive strength over the freeze-dried ones 167 , suggesting that even at the final processing stages changes can occur that dramatically affect the interaction of the components at the nano and molecular scales. After all, if sheer solvent desorption and resorption was enough to cause reversible structural transformations in 3-nm-sized zinc sulfide particles 168 , the structure of softer nanoparticles must be even more amenable to such post-processing effects.…”

Section: Other Composite Materialsmentioning

confidence: 98%

When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications

Uskoković

2015

Materials Science and Engineering: C

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Multicomponent, synergistic and multifunctional nanostructures have taken over the spotlight in the realm of biomedical nanotechnologies. The most prospective materials for bone regeneration today are almost exclusively composites comprising two or more components that compensate for the shortcomings of each one of them alone. This is quite natural in view of the fact that all hard tissues in the human body, except perhaps the tooth enamel, are composite nanostructures. This review article highlights some of the most prospective breakthroughs made in this research direction, with the hard tissues in main focus being those comprising bone, tooth cementum, dentin and enamel. The major obstacles to creating collagen/apatite composites modeled after the structure of bone are mentioned, including the immunogenicity of xenogeneic collagen and continuously failing attempts to replicate the biomineralization process in vitro. Composites comprising a polymeric component and calcium phosphate are discussed in light of their ability to emulate the soft/hard composite structure of bone. Hard tissue engineering composites created using hard material components other than calcium phosphates, including silica, metals and several types of nanotubes, are also discoursed on, alongside additional components deliverable using these materials, such as cells, growth factors, peptides, antibiotics, antiresorptive and anabolic agents, pharmacokinetic conjugates and various cell-specific targeting moieties. It is concluded that a variety of hard tissue structures in the body necessitates a similar variety of biomaterials for their regeneration. The ongoing development of nanocomposites for bone restoration will result in smart, theranostic materials, capable of acting therapeutically in direct feedback with the outcome of in situ disease monitoring at the cellular and subcellular scales. Progress in this research direction is expected to take us to the next generation of biomaterials, designed with the purpose of fulfilling Daedalus’ dream - not restoring the tissues, but rather augmenting them.

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“…Also, another study reported that an inorganic bovine bone has no osteoinductivity and its granular form makes it difficult to be fixed on surgical sites. Moreover, the bovine xenograft is non-absorbable in vivo [58].…”

Section: (Iii) Xenograftsmentioning

confidence: 99%

Past, Present, and Future of Regeneration Therapy in Oral and Periodontal Tissue: A Review

et al. 2019

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Chronic periodontitis is the most common disease which induces oral tissue destruction. The goal of periodontal treatment is to reduce inflammation and regenerate the defects. As the structure of periodontium is composed of four types of different tissue (cementum, alveolar bone periodontal ligament, and gingiva), the regeneration should allow different cell proliferation in the separated spaces. Guided tissue regeneration (GTR) and guided bone regeneration (GBR) were introduced to prevent epithelial growth into the alveolar bone space. In the past, non-absorbable membranes with basic functions such as space maintenance were used with bone graft materials. Due to several limitations of the non-absorbable membranes, membranes of the second and third generation equipped with controlled absorbability, and a functional layer releasing growth factors or antimicrobials were introduced. Moreover, tissue engineering using biomaterials enabled faster and more stable tissue regeneration. The scaffold with three-dimensional structures manufactured by computer-aided design and manufacturing (CAD/CAM) showed high biocompatibility, and promoted cell infiltration and revascularization. In the future, using the cell sheath, pre-vascularizing and bioprinting techniques will be applied to the membrane to mimic the original tissue itself. The aim of the review was not only to understand the past and the present trends of GTR and GBR, but also to be used as a guide for a proper future of regeneration therapy in the oral region.

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Balancing mechanical strength with bioactivity in chitosan–calcium phosphate 3D microsphere scaffolds for bone tissue engineering: air- vs. freeze-drying processes

Cited by 25 publications

References 22 publications

Bone regenerative medicine: classic options, novel strategies, and future directions

Bone regenerative medicine: classic options, novel strategies, and future directions

When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications

Past, Present, and Future of Regeneration Therapy in Oral and Periodontal Tissue: A Review

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