Balancing firing rates in vivo

Whalley, Katherine

doi:10.1038/nrn3637

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Furthermore, these observations were observed specifically in VTA DA neurons projecting to NAc but not mPFC, which correlates with previous projecting specific roles in encoding for depression [163]. Homeostatic plasticity plays a fundamental role in stabilizing neuronal activity in response to excessive perturbations under both physiological [248, 249] and disease[250] conditions. Previous molecular analysis had shown that mice resilient to CSD stress exhibited normalized firing activity in VTA DA neurons associated with a corresponding increase in genes coding for subtype of K + channels [12].…”

Section: Homeostatic Adaptationssupporting

confidence: 84%

Neuronal correlates of depression

Chaudhury

Liu

Han

2015

Cell. Mol. Life Sci.

112

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Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately 121 million people worldwide and recent reports from the World Health Organization (WHO) suggest that it will be the leading contributor to the global burden of diseases. At present the most commonly used treatment strategies are still based on the monoamine hypothesis that has been the predominant theory in the last 60 years. Clinical observations that only a subset of depressed patients exhibits full remission when treated with classical monoamine-based antidepressants together with the fact that patients exhibit multiple symptoms suggest that the pathophysiology leading to mood disorders may differ between patients. Accumulating evidence indicates that depression is a neural circuit disorder and that onset of depression may be located at different regions of the brain involving different transmitter systems and molecular mechanisms. This review synthesizes findings from rodent studies from which emerges a role for different, yet interconnected, molecular systems and associated neural circuits to the etiology of depression.

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Section: Homeostatic Adaptationssupporting

confidence: 84%

Neuronal correlates of depression

Chaudhury

Liu

Han

2015

Cell. Mol. Life Sci.

112

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“…We also thank S. J. Russo, H. P. Xu, J. L. Cao, F. Henn, and E. J. S1 and S2 References (26)(27)(28)(29)(30)(31)(32)(33) Movies S1 to S3…”

Section: Acknowledgmentsmentioning

confidence: 99%

Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex

Tomassy

Berger

Chen

et al. 2014

Science

469

474

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Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of the myelin envelope is a structural feature affecting the conduction of neuronal signals. Conversely, the distribution of myelinated tracts along the length of axons has been assumed to be uniform. Here, we traced high-throughput electron microscopy (EM) reconstructions of single axons of pyramidal neurons in the mouse neocortex and built high-resolution maps of myelination. We find that individual neurons have distinct longitudinal distribution of myelin. Neurons in the superficial layers displayed the most diversified profiles, including a new pattern where myelinated segments are interspersed with long, unmyelinated tracts. Our data indicate that the profile of longitudinal distribution of myelin is an integral feature of neuronal identity and may have evolved as a strategy to modulate long-distance communication in the neocortex.

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“…Evidence demonstrates that homeostatic plasticity plays a fundamental role in stabilizing neuronal activity in response to excessive perturbations under both physiological (30, 31) and disease (32) conditions. We observed that resilient mice displayed enhanced I h current in VTA DA neurons, and simultaneously exhibited up-regulated inhibitory K + currents.…”

mentioning

confidence: 99%

“…Self-tuning adaptation of neuronal activity as a homeostatic plasticity concept was first described in primary neuronal culture (27) and further observed in in vivo animal models (28,29). Evidence shows that homeostatic plasticity plays a fundamental role in stabilizing neuronal activity in response to excessive perturbations under both physiological (30,31) and disease (32) conditions. We observed that resilient mice displayed enhanced I h current in VTA DA neurons and simultaneously exhibited up-regulated inhibitory K + currents.…”

mentioning

confidence: 99%

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

Friedman

Walsh

Juarez

et al. 2014

Science

385

444

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Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects by enhancing depression-causing mechanisms in ventral tegmental area (VTA) dopamine (DA) neurons. In a social defeat stress model of depression, depressed (susceptible) mice display hyperactivity of VTA DA neurons, caused by an up-regulated hyperpolarization-activated current (Ih). Mice resilient to social defeat stress, however, exhibit stable normal firing of these neurons. Unexpectedly, resilient mice had an even larger Ih, which was observed in parallel with increased potassium (K+) channel currents. Experimentally enhancing the firing-increasing Ih or optogenetically increasing the hyperactivity of VTA DA neurons in susceptible mice, completely reversed depression-related behaviors, an antidepressant effect achieved through resilience-like, projection-specific homeostatic plasticity. These results indicate a potential therapeutic path of promoting natural resilience for depression treatment.

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Balancing firing rates in vivo

Cited by 6 publications

References 2 publications

Neuronal correlates of depression

Neuronal correlates of depression

Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

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