Balanced T_H1 and T_H2 immunopotentiating effects of silicates partly containing nanoparticles present in calcined serpentine

Abstract

Calcined Serpentine (CS) is used in various formulations of alternative systems of medicine as a tonic to vital organs and as an anti-inflammatory agent. The process of calcination or incineration is believed to render non-toxic, gently absorbable, adaptable and digestible properties to the mineral compounds. The present study characterized CS and also evaluated its immunostimulatory potential. CS was characterized by using transmission electron microscopy (TEM), X-ray powder diffraction, atomic absorption spectroscopy and CHNS analysis. The characterized CS was further evaluated for its immunomodulatory potential in Swiss mice. X-Ray diffraction analysis revealed that the CS contained silicates of magnesium, calcium and iron as major minerals. Elemental composition and heavy metal analyses showed a presence of various inorganic elements/heavy metals, albeit at levels well below daily permissive intake values.

Pru p 3‐Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T‐Cells from LTP‐Allergic Patients

“…The differential expression of CCR7 between groups may be associated with the capacity of D n ManPrup3 to stimulate complete DC maturation, activation and DC survival, leading to interactions with other immune cells and the differentiation of naive T‐cells . Our results also show that the presence of D n ManPrup3 induces specific T‐ and B‐cell proliferation with a Th2 response pattern (significant increases in IL‐13 and IL‐4, with low levels of IL‐10) as reported previously . These results suggest that the T‐cell epitope of Pru p 3 in the GDPs stimulates DC maturation and allergen‐specific T‐cell proliferation, inducing an immune response similar to that of the native allergen.…”

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

“…The potential for such effects to specifically impact allergic disease processes has been illustrated by a few studies. For example, ingestion of SiNP and PtNP were associated with increases in antigen-specific antibody production following immunization of mice and rabbits (956,958). Interestingly, oral administration of AgNP has been shown to block the development of oral tolerance to OVA in sensitized mice, directly demonstrating the potential for metal nanomaterials to augment allergic disease resulting from an often overlooked route of exposure (800).…”