Balanced Expression of G Protein-coupled Receptor Subtypes in the Mouse, Macaque, and Human Cerebral Cortex

Treviño, Mario; Manjarrez, Elı́as

doi:10.1016/j.neuroscience.2022.01.028

Cited by 3 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such system bias can be modulated further through differential expression of also the receptors and multiple downstream intracellular effectors ( Kolb et al, 2022 ). A recent study found a strong spatial correlation of summed mRNA expression levels for G s -, G i/o -, and G q/11 -linked receptors in humans, macaques, and mice ( Treviño and Manjarrez, 2022 ). This suggests that the expression patterns of receptors linked to these major G protein families are strongly interdependent and could therefore act together to balance each other in specific tissues.…”

Section: Discussionmentioning

confidence: 99%

Common coupling map advances GPCR-G protein selectivity

Hauser

Avet

Normand

et al. 2022

eLife

View full text Add to dashboard Cite

Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors that couple to G proteins to achieve appropriate functional responses. While G protein transducers from literature are annotated in the Guide to Pharmacology database, two recent large-scale datasets now expand the receptor-G protein 'couplome'. However, these three datasets differ in scope and reported G protein couplings giving different coverage and conclusions on GPCR-G protein signaling. Here, we report a common coupling map uncovering novel couplings supported by both large-scale studies, the selectivity/promiscuity of GPCRs and G proteins, and how the co-coupling and co-expression of G proteins compare to the families from phylogenetic relationships. The coupling map and insights on GPCR-G protein selectivity will catalyze advances in receptor research and cellular signaling towards the exploitation of G protein signaling bias in design of safer drugs.

show abstract

Section: Discussionmentioning

confidence: 99%

Common coupling map advances GPCR-G protein selectivity

Hauser

Avet

Normand

et al. 2022

eLife

View full text Add to dashboard Cite

show abstract

“…Such system bias can be modulated further through differential expression of also the receptors and multiple downstream intracellular effectors (22). A recent study found a strong spatial correlation of summed mRNA expression levels for G s -, G i/o -, and G q/11 -linked receptors in humans, macaques, and mice (23). This suggests that the expression patterns of receptors linked to these major G protein families are strongly interdependent and could therefore act together to balance each other in specific tissues.…”

Section: Discussionmentioning

confidence: 99%

Common coupling map advances GPCR-G protein selectivity

Hauser

Avet

Normand³

et al. 2021

Preprint

View full text Add to dashboard Cite

Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors that couple to G proteins to achieve appropriate functional responses. While G protein transducers from literature are annotated in the Guide to Pharmacology database, two recent large-scale datasets now expand the receptor-G protein couplome. However, these three datasets differ in scope and reported G protein couplings giving different coverage and conclusions on GPCR-G protein signaling. Here, we report a meta-analysis unifying GPCR-G protein coupling, by standardized normalization and consensus support, into a common coupling map. This unravels novel consensus couplings for receptors supported by two independent sources and insights on coupling selectivity of GPCRs and classification of co-coupling G proteins. The coupling protocol, map and selectivity resources will promote advances in receptor research and cellular signaling towards the exploitation of G protein signaling specificity in design of safer drugs.

show abstract

Visuomotor predictors of interception

Márquez,

Treviño

2024

PLoS ONE

View full text Add to dashboard Cite

Intercepting moving targets is a fundamental skill in human behavior, influencing various domains such as sports, gaming, and other activities. In these contexts, precise visual processing and motor control are crucial for adapting and navigating effectively. Nevertheless, there are still some gaps in our understanding of how these elements interact while intercepting a moving target. This study explored the dynamic interplay among eye movements, pupil size, and interceptive hand movements, with visual and motion uncertainty factors. We developed a simple visuomotor task in which participants used a joystick to interact with a computer-controlled dot that moved along two-dimensional trajectories. This virtual system provided the flexibility to manipulate the target’s speed and directional uncertainty during chase trials. We then conducted a geometric analysis based on optimal angles for each behavior, enabling us to distinguish between simple tracking and predictive trajectories that anticipate future positions of the moving target. Our results revealed the adoption of a strong interception strategy as participants approached the target. Notably, the onset and amount of optimal interception strategy depended on task parameters, such as the target’s speed and frequency of directional changes. Furthermore, eye-tracking data showed that participants continually adjusted their gaze speed and position, continuously adapting to the target’s movements. Finally, in successful trials, pupillary responses predicted the amount of optimal interception strategy while exhibiting an inverse relationship in trials without collisions. These findings reveal key interactions among visuomotor parameters that are crucial for solving complex interception tasks.

show abstract

Balanced Expression of G Protein-coupled Receptor Subtypes in the Mouse, Macaque, and Human Cerebral Cortex

Cited by 3 publications

References 50 publications

Common coupling map advances GPCR-G protein selectivity

Common coupling map advances GPCR-G protein selectivity

Common coupling map advances GPCR-G protein selectivity

Visuomotor predictors of interception

Contact Info

Product

Resources

About