2013
DOI: 10.1093/bja/aes377
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Balanced crystalloid compared with balanced colloid solution using a goal-directed haemodynamic algorithm

Abstract: Using a goal-directed haemodynamic algorithm to optimize stroke volume, a balanced HES solution is associated with better haemodynamic stability and reduced need for fresh-frozen plasma. There were no signs of renal impairment by colloid solutions when fluid administration is targeted to optimize cardiac preload.

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Cited by 138 publications
(119 citation statements)
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“…They found no difference in outcomes although, similar to a previous study, 60% more fluid was needed in the crystalloid group [73]. Therefore, in clinical practice without significant hypovolemia, the colloid-to-crystalloid ratio appears to be approximately 1:1.5 [72,73].…”
Section: Recent Studies Of Gdft Within An Enhanced Recovery Programsupporting
confidence: 72%
See 1 more Smart Citation
“…They found no difference in outcomes although, similar to a previous study, 60% more fluid was needed in the crystalloid group [73]. Therefore, in clinical practice without significant hypovolemia, the colloid-to-crystalloid ratio appears to be approximately 1:1.5 [72,73].…”
Section: Recent Studies Of Gdft Within An Enhanced Recovery Programsupporting
confidence: 72%
“…They found no difference in outcomes although, similar to a previous study, 60% more fluid was needed in the crystalloid group [73]. Therefore, in clinical practice without significant hypovolemia, the colloid-to-crystalloid ratio appears to be approximately 1:1.5 [72,73]. However, the volume effect of colloids is context sensitive [14], and when hypovolemia is present, the colloid-to-crystalloid ratio may be higher [71].…”
Section: Recent Studies Of Gdft Within An Enhanced Recovery Programsupporting
confidence: 64%
“…This should be given rapidly over five to ten minutes, 23 and although there is no consensus on the type of fluid given, most trials in the operating room showing an improved outcome were performed with a colloid. [24][25][26][27][28][29][30][31][32] Importantly, hemodynamic instability does not equate with volume responsiveness; indeed, only 50% of hemodynamically unstable patients in the operating room are ''volume responders''. 33 Moreover, volume responsiveness does not always mean that a fluid bolus is needed.…”
Section: Maintenance Fluid Therapymentioning
confidence: 99%
“…HES solutions have gained popularity because of its efficacy as volume expanders in treating hypovolemic patients when compared with crystalloids. 3 This view point aims to emphasize some of the safety issues and concerns regarding routine usage of HES products. The unfavorable interaction of HES molecule with the coagulation pathways with resultant impaired blood clotting has always been a matter of concern.…”
mentioning
confidence: 99%