Balanced Anesthesia with Nalbuphine Hydrochloride

Magruder, Michael R.; Christofforetti, R.; DiFazio, Cosmo A.; Wyant, Gordon M.

doi:10.1097/00132586-198108000-00039

Cited by 4 publications

(2 citation statements)

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“…The dose-related respiratory depression associated with nalbuphine reaches maximal effect at 0.4 mg per kg, and dosages in excess of this amount result in little, if any, additional respiratory depression. Nalbuphine, a new non-opiate narcotic, is characterized by ceiling respiratory depression (11) and maximal analgesic effect (12,13) without apparent ceiling sedative effect (14). The ceiling respiratory depression is a built in safety factor which assures an acceptable level of respiratory activity consistent with adaquate ventilation.…”

Section: Discussionmentioning

confidence: 99%

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Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion

Klein

Mahaley

1986

J Neuro-Oncol

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A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas. This regimen consists of nalbuphine, 30 mg, i.v., and droperidol, 2.5 mg, i.v., given immediately prior to intra-carotid BCNU infusion. Droperidol, 2.5 mg, i.v., is then administered on four hour intervals for sixteen hours post-procedure. This combination provided excellent effect in nine patients treated for twelve intra-carotid infusions. None of the nine patients experienced vomiting, one experienced mild nausea several hours post-infusion, and non complained of severe pain or discomfort. Thirteen additional patients received diazepam, 10 mg, P.O., prior to the intra-carotid BCNU infusion, with fentanyl, 100 mcg, i.v., and prochlorperazine, 10 mg, i.m. at the onset of infusion. All thirteen patients suffered from severe nausea, vomiting, and orbital pain. The nalbuphine/droperidol combination is thought to provide a superior alternative to the traditional narcotic/pheonothiazine/benzodiazepine combination for carotid BCNU infusion. This combination has theoretical advantages for the patient with intracranial mass lesions by providing analgesia and sedation with minimal potential for respiratory depression and carbon dioxide retention.

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Section: Discussionmentioning

confidence: 99%

“…The respiratory depression characteristic of other narcotics is therefore less of a concern. Sedation associated with the 30 mg/70 kg (0.4 mg per kg) nalbuphine dosage is seen as a desirable therapeutic side effect (14), and, under most circumstances, provides a satisfactory level of analgesia.…”

Section: Discussionmentioning

confidence: 99%

Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion

Klein

Mahaley

1986

J Neuro-Oncol

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High dose nalbuphine in early acute myocardial infarction

Trouton

Adgey

1989

International Journal of Cardiology

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Comparison of Nalbuphine, Pethidine and Placebo as Premedication for Minor Gynaecological Surgery

Chestnutt

Clarke

Dundee

1987

British Journal of Anaesthesia

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In a randomized double-blind placebo-controlled trial involving 80 patients nalbuphine 10 mg and 20 mg were compared with pethidine 100 mg and a placebo given i.m. at least 90 min before minor gynaecological surgery. Nalbuphine proved a suitable alternative to pethidine, producing beneficial sedation which was maximum at 60 min after injection. Both nalbuphine and pethidine reduced the excitatory sequelae of methohexitone induction. Increasing the dose of nalbuphine from 10 mg to 20 mg produced no significant additional sedation or intraoperative benefit. Short-lived pain at the injection site was a feature of the use of nalbuphine in either dose. The main disadvantage of nalbuphine was nausea and vomiting of delayed onset, the frequency of which was similar after either dose.

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Balanced Anesthesia with Nalbuphine Hydrochloride

Cited by 4 publications

References 0 publications

Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion

Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion

High dose nalbuphine in early acute myocardial infarction

Comparison of Nalbuphine, Pethidine and Placebo as Premedication for Minor Gynaecological Surgery

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