Balance of Increases and Decreases in Firing Rate of the Spontaneous Activity of Basal Ganglia High-Frequency Discharge Neurons

Elias, Shlomo; Ritov, Ya’acov; Bergman, Hagai

doi:10.1152/jn.90714.2008

Cited by 16 publications

(13 citation statements)

References 88 publications

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“…Contrasting with the report of Tang et al (2007), firing rates of neurons in the GPe (mean rate, 52 Hz) in our study were significantly lower than in GPi but also lower compared to the mean rates of ~65 Hz that are typically found in the GPe of healthy monkeys (Wichmann et al, 2002; Starr et al, 2005; Elias et al, 2008; Erez et al, 2011). Instead, average GPe rates were in the same range as values reported for patients suffering from Parkinson's disease (Favre et al, 1999; Starr et al, 2005; Tang et al, 2007).…”

Section: Discussioncontrasting

confidence: 99%

“…This is in excellent agreement with the mean rate of 71 Hz that was reported by the only available study investigating pallidal discharges in a cohort of CD patients (Tang et al, 2007). Thus, internal pallidal discharge rates of CD patients are grosso modo similar to those being reported for healthy nonhuman primates (Filion and Tremblay, 1991; Wichmann et al, 2002; Starr et al, 2005; Elias et al, 2008; Erez et al, 2011) but considerably higher compared to the generally low GPi rates reported for patients with other types of dystonia, in particular generalized forms (Vitek et al, 1999; Sanghera et al, 2003; Merello et al, 2004; Starr et al, 2005; Zittel et al, 2009). …”

Section: Discussionsupporting

confidence: 76%

“…This ratio was 0.73 in our study, which is in-between the generally lower values (~0.6) reported for this ratio in PD (Starr et al, 2005; Tang et al, 2007) and GPe:GPi firing frequency ratios of ~0.8–1 in recordings from healthy primates (Starr et al, 2005; Elias et al, 2008; Erez et al, 2011). …”

Section: Discussionsupporting

confidence: 53%

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Asymmetric pallidal neuronal activity in patients with cervical dystonia

Moll

Galindo-Leon

Sharott

et al. 2014

Front. Syst. Neurosci.

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The origin of asymmetric clinical manifestation of symptoms in patients suffering from cervical dystonia (CD) is hitherto poorly understood. Dysregulated neuronal activity in the basal ganglia has been suggested to have a role in the pathophysiology of CD. Here, we re-assessed the question to what extent relative changes occur in the direct vs. indirect basal ganglia pathway in CD, whether these circuit changes are lateralized, and how these alterations relate to CD symptoms. To this end, we recorded ongoing single cell and local field potential (LFP) activity from the external (GPe) and internal pallidal segment (GPi) of 13 CD patients undergoing microelectrode-guided stereotactic surgery for deep brain stimulation in the GPi. We compared pallidal recordings from CD patients operated under local anaesthesia (LA) with those obtained in CD patients operated under general anaesthesia (GA). In awake patients, mean GPe discharge rate (52 Hz) was lower than that of GPi (72 Hz). Mean GPi discharge ipsilateral to the side of head turning was higher than contralateral and correlated with torticollis symptom severity. Lateralized differences were absent at the level of the GPe and in recordings from patients operated under GA. Furthermore, in the GPi of CD patients there was a subpopulation of theta-oscillatory cells with unique bursting characteristics. Power and coherence of GPe– and GPi–LFPs were dominated by a theta peak and also exhibited band-specific interhemispheric differences. Strong cross-frequency coupling of low-gamma amplitude to theta phase was a feature of pallidal LFPs recorded under LA, but not GA. These results indicate that CD is associated with an asymmetric pallidal outflow. Based on the finding of symmetric neuronal discharges in the GPe, we propose that an imbalanced interhemispheric direct pathway gain may be involved in CD pathophysiology.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Asymmetric pallidal neuronal activity in patients with cervical dystonia

Moll

Galindo-Leon

Sharott

et al. 2014

Front. Syst. Neurosci.

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“…A possible explanation for this may lie in the uncorrelated nature of abnormal GPe activity observed in this study. GPe activation was shown to be able to effectively influence the activity of GPi neurons (Kita 2007), but due to the diffused pattern of GPe-GPi connectivity a synchronized activation of the GPe (or a subgroup of its neurons) is needed to effectively influence the GPi (Kita 2007 animals there is little or no correlated activity between individual GPe-GPi neurons (Elias et al 2008;Raz et al 2000). GPe-GPi correlations have been shown to emerge in some pathological conditions in which the GPe neurons throughout the nucleus fire in a synchronized manner Raz et al 2000).…”

Section: B Amentioning

confidence: 99%

Bicuculline-Induced Chorea Manifests in Focal Rather Than Globalized Abnormalities in the Activation of the External and Internal Globus Pallidus

Bronfeld

Belelovsky

Erez

et al. 2010

Journal of Neurophysiology

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Chorea is a basal-ganglia (BG) related hyperkinetic movement disorder characterized by irregular continuous involuntary movements. Chorea and related hyperbehavioral disorders may be induced in behaving primates by local microinjections of the GABA(A) antagonist bicuculline to the globus pallidus externus (GPe). We performed multielectrode extracellular recordings in the GPe and in the globus pallidus internus (GPi) before, during, and after bicuculline microinjections. Bicuculline led to an increase in the firing rate and a change in the firing pattern of GPe neurons. Two types of abnormal neuronal firing patterns were detected in GPe neurons close to the bicuculline microinjection site: continuous high-frequency activity and bistable activity, in which neurons transitioned between high-frequency and complete cessation of firing. Neuronal activity remained uncorrelated within and between the GPe and the GPi, with no evidence for propagation of the focal GPe abnormal activity downstream to the GPi. Despite reduction in the information capacity of bicuculline-affected GPe neurons, the ability to encode behavioral events was maintained. We found similar responses of GPe neurons to bicuculline in vitro in the rat, suggesting a basic cellular mechanism underlying these abnormal firing patterns. These results demonstrate that chorea is associated with focal neuronal changes that are not complemented by global changes in the BG nuclei. This suggests a mechanism of stochastic phasic alteration of BG control leading to the chaotic nature of chorea. Thus rather than imposing a globalized state of cortical excitability, chorea might be associated with changes in internal information processing within the BG.

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“…In particular, we aimed to solve the apparent contradiction between a) anatomical studies showing that the GPi is an important target of a gabaergic inhibition from GPe [3] that is further thought to be powerful, as the synaptic targets in GPi are close to the soma [4], and b) electrophysiological studies that record very similar activities in both nuclei, at rest [5], in directional arm reaching tasks [6] and during eye closures [7]. Furthermore, the BG are supposedly the substrates of a generic selection process among cortical inputs, but the classical explanation of this selection stemming from the segregation between a direct pathway (with the "direct" striatal neurons targeting straight the GPi) and an indirect pathway (with the "indirect" striatal neurons targeting the GPe) is not compatible with primate anatomical data showing a nearly total overlap in the efferences of the striatal neurons.…”

mentioning

confidence: 99%