Balance between pro and anti-inflammatory cytokines in patients with acute alcoholic hepatitis

Naveau, Sylvie; Balian, Axel; Capron, Frédérique; Raynard, Bruno; Fallik, David; Agostini, Hélène; Grangeot-Keros, L.; Portier, A; Galanaud, Pierre; Chaput, Jean‐Claude; Émilie, Dominique

doi:10.1016/s0399-8320(05)80760-2

Cited by 36 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This apoptosis phenomenon may follow the degranulation of neutrophils, which may cause necrosis of ballooning hepatocytes, leading to the formation of Mallory bodies. [40][41][42] The hypothesis that neutrophil-mediated liver cell injury plays a significant role in AAH agrees with many observations made 38 by examining liver sections obtained from patients with AH: extravasated neutrophils in the liver were found, as well as degranulation of neutrophils and excessive formation of neutrophil chemo-attractants such as chemokines in liver cells. Colocalization and a strong quantitative correlation between apoptotic hepatocytes and neutrophils could indicate apoptosis-induced transmigration of neutrophils during AH, similar to events previously demonstrated in experimental models.…”

Section: Pathologysupporting

confidence: 87%

“…38,39 Endotoxinemia and alcohol-induced elevation of IL-8 may play an important role in the activation and migration of neutrophils in patients with AH. 40 In AAH, neutrophil granulocytes that infiltrate liver parenchyma show an activation-induced cell deathlike phenomenon, similar to the infiltration of activated T cells in viral hepatitis. This apoptosis phenomenon may follow the degranulation of neutrophils, which may cause necrosis of ballooning hepatocytes, leading to the formation of Mallory bodies.…”

Section: Pathologymentioning

confidence: 98%

See 1 more Smart Citation

Acute Alcoholic Hepatitis

Ceccanti¹,

Attili

Balducci

et al. 2006

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

Acute alcoholic hepatitis (AAH) is a frequent inflammatory liver disease with high short-term mortality rate. In this review, relationships between alcohol abuse and the epidemiology and the outcomes of AAH are discussed, as well as AAH pathogenesis. The role of endotoxins, tumor necrosis factor alpha, fibroblasts, and immune response to altered hepatocyte proteins is discussed. The need of a careful prognosis, supported by the use of Maddrey score, by the model for end-stage liver disease [Mayo end-stage liver disease (MELD)] score or by the Glasgow alcoholic hepatitis score, is outlined, as the use of the most effective drugs (glucocorticoids and anti-tumor necrosis factor alpha infliximab) is recommended only in severe AAH cases. The problems of liver transplant in severe AAH, and the need of a 6-month alcohol abstinence before transplant, are discussed, as well as the need of a careful psychologic assessment before the transplant.

show abstract

Section: Pathologysupporting

confidence: 87%

Section: Pathologymentioning

confidence: 98%

Acute Alcoholic Hepatitis

Ceccanti¹,

Attili

Balducci

et al. 2006

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

show abstract

“…Cytokine measurements are shown together with reports from the literature [4,5,[9][10][11][12], for proper perspective (Table 3). …”

Section: Resultsmentioning

confidence: 99%

Pro- and Anti-inflammatory Cytokines in Steatosis and Steatohepatitis

et al. 2010

View full text Add to dashboard Cite

(1) Generally inconsistent changes in pro- and anti-inflammatory cytokines occurred when NASH was globally compared to steatosis. (2) In contrast, downregulation of IL-6 and IL-10 was perceived in diabetics with NASH. (3) Arterial hypertension did not play a role in these circumstances. (4) IL-10 maintained strong correlations with glucose metabolism indices. (5) TNF-alpha could not be incriminated for progressive liver damage, as values failed to increase in NASH. (6) Investigations of IL-10 and other counterregulatory cytokines are lacking in this context and deserve further studies.

show abstract

“…As it is well known, immune mechanisms play a very important role in the initiation and progression of certain liver diseases, such as acute viral hepatitis and alcohol or drug induced hepatitis (Naveau et al, 2005;Corazza et al, 2009). Activated by endotoxemia, inflammatory cells (mostly macrophages, including Kupffer cells) produce pro-inflammatory mediators and cytokines.…”

Section: Discussionmentioning

confidence: 99%