BAL fluid cells and pulmonary function in different radiographic stages of newly diagnosed sarcoidosi

Danila, Edvardas; Jurgauskienė, Laimutė; Malickaitė, Radvilė

doi:10.2478/v10039-008-0014-z

Cited by 30 publications

(34 citation statements)

References 22 publications

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“…They found the discordance between pulmonary function data and chest X-ray data in 50% of cases and concluded that changes in radiographic extent are more applicable to routine monitoring in sarcoidosis than change in radiographic stages. PFT parameters decrease in higher radiographic stages (17,35,36). We found that the percentage of BALF lymphocytes and macrophages correlated with the TLC values: the percentage of lymphocytes correlated negatively and the percentage of macrophages correlated positively.…”

Section: Discussionmentioning

confidence: 57%

“…However, cellular components of BALF and T lymphocyte profiles are associated with several situations, such as clinical presentation, radiological stage and smoking status (17,18). A high relative CD4 + T lymphocyte number (percentage) and high CD4/CD8 ratio, increased alveolar macrophages amount in BALF reflect an active inflammatory process in the lung.…”

Section: Discussionmentioning

confidence: 99%

“…It is thought that the increased BALF neutrophil and/or eosinophil count is associated with a more advanced, chronic disease course (17,(31)(32)(33). The increase of the macrophages and neutrophil count, decrease of lymphocyte count and CD4/CD8 ratio with increased radiographic stage of sarcoidosis in BALF in patient with newly diagnosed sarcoidosis have been documented (17,23). In line with these observations, we found significant differences (P=0.021) between the percentage of neutrophils of BALF in radiographic stages I and III in our sample.…”

Section: Discussionmentioning

confidence: 99%

“…BALF analysis was performed as described in previous publications (17,18). We used the same BAL and BALF methods of analysis throughout the study period.…”

Section: Bronchoscopy and Bronchoalveolar Lavagementioning

confidence: 99%

“…Recently, the correlation between disease severity in CT, functional impairment and radiographic stages of sarcoidosis, as well as pulmonary function tests (PFT) and bronchoalveolar lavage fluid (BALF) cells, have been discussed in the literature (5,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). However, few systematic evaluations exist exploring the relationships between the various HRCT findings (e.g., micronodules, macronodules, irregular linear opacities, interlobular septal thickening, fibrotic changes, etc.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

Aleksonienė¹,

Zeleckienė²,

Matačiūnas³

et al. 2017

J. Thorac. Dis.

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Background: The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead to optimize of the patient follow-up frequency. Methods: Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed tomography (HRCT) examination, pulmonary function tests (PFT), bronchoscopy with bronchoalveolar lavage (BAL) and lung biopsy, and bronchoalveolar lavage fluid (BALF) cell examination. Results: The reduction in PFT values seen in radiological sarcoidosis stage III was greater than that seen in stages I and II. The percentage of neutrophils in the lungs was found to increase in stages II and III. PFT indices were correlated negatively with the consolidation and ground glass opacities CT scores, but not with the micronodule or macronodule scores. The rise in the percentage of BALF lymphocytes was associated with the restriction pattern of PFT. The diagnostic value of BALF for sarcoidosis was higher when the typical radiologic patterns of stage I disease were found and that smoking decreased the diagnostic value of CD4/CD8 ratio. Conclusions: This study supports the opinion that the staging of the pulmonary sarcoidosis with chest X-rays is still valuable from the prognostic point of view, because significant correlations between the radiologic stages of sarcoidosis and PFT parameters were found. Chest HRCT was significantly superior to chest X-ray in detecting mediastinal and pulmonary parenchymal changes. However, the prognostic role of HRCT needs to be better investigated evaluating serial examinations. Only consolidation and ground glass scores (neither of which are frequently found in sarcoidosis) hold prognostic value, since these were negatively correlated with PFT parameters.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…BALF analysis was performed as described in previous publications (17,18). We used the same BAL and BALF methods of analysis throughout the study period.…”

Section: Bronchoscopy and Bronchoalveolar Lavagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

Aleksonienė¹,

Zeleckienė²,

Matačiūnas³

et al. 2017

J. Thorac. Dis.

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Diagnostic Performance of Bronchoalveolar Lavage Fluid CD4/CD8 Ratio for Sarcoidosis: A Meta-analysis

Shen¹,

Pang²,

et al. 2016

EBioMedicine

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BackgroundThe usefulness of bronchoalveolar lavage fluid (BALF) CD4/CD8 ratio for diagnosing sarcoidosis has been reported in many studies with variable results. Therefore, we performed a meta-analysis to estimate the overall diagnostic accuracy of BALF CD4/CD8 ratio based on the bulk of published evidence.MethodsStudies published prior to June 2015 and indexed in PubMed, OVID, Web of Science, Scopus and other databases were evaluated for inclusion. Data on sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were pooled from included studies. Summary receiver operating characteristic (SROC) curves were used to summarize overall test performance. Deeks's funnel plot was used to detect publication bias.ResultsSixteen publications with 1885 subjects met our inclusion criteria and were included in this meta-analysis. Summary estimates of the diagnostic performance of the BALF CD4/CD8 ratio were as follows: sensitivity, 0.70 (95%CI 0.64–0.75); specificity, 0.83 (95%CI 0.78–0.86); PLR, 4.04 (95%CI 3.13–5.20); NLR, 0.36 (95%CI 0.30–0.44); and DOR, 11.17 (95%CI 7.31–17.07). The area under the SROC curve was 0.84 (95%CI 0.81–0.87). There was no evidence of publication bias.ConclusionMeasuring the BALF CD4/CD8 ratio may assist in the diagnosis of sarcoidosis when interpreted in parallel with other diagnostic factors.

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Leaving History Behind: CD4/CD8 Ratio as a Diagnostic Tool in Sarcoidosis

James

2016

EBioMedicine

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BAL fluid cells and pulmonary function in different radiographic stages of newly diagnosed sarcoidosi

Cited by 30 publications

References 22 publications

Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

Diagnostic Performance of Bronchoalveolar Lavage Fluid CD4/CD8 Ratio for Sarcoidosis: A Meta-analysis

Leaving History Behind: CD4/CD8 Ratio as a Diagnostic Tool in Sarcoidosis

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