Bakteriämie und Sepsis

Hagel, Stefan; Pletz, Mathias W.; Brunkhorst, Frank M.; Seifert, Harald; Kern, Winfried V.

doi:10.1007/s00108-012-3185-4

Cited by 17 publications

(17 citation statements)

References 31 publications

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“…In addition to animal selection and sampling period, the sampling interval, storage and transport of samples are also important for detecting live pathogens [21]. The site of collection and adequate preparation thereof by shaving and disinfecting are important.…”

Section: Discussionmentioning

confidence: 99%

“…A differentiated consideration of the terms bacteremia and sepsis is required when defining the term "bacteremia". While bacteremia is defined as the presence of bacteria in the blood [20], sepsis is a generalized inflammatory response, a clinical diagnosis, that requires further specification regarding the source of infection and the etiologic pathogen [21].…”

Section: Introductionmentioning

confidence: 99%

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Are Severe Mastitis Cases in Dairy Cows Associated with Bacteremia?

Brennecke¹,

Falkenberg²,

Wente³

et al. 2021

Animals

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The objective of this study was to investigate the occurrence of bacteremia in dairy cows with severe mastitis. Milk samples were collected from affected udder quarters, and corresponding blood samples were collected from dairy cows with severe mastitis at the time of diagnosis before any therapeutic measures were undertaken. The cultural detection of pathogens in blood classified a bacteremia. Further diagnostic tests were performed to provide evidence of bacteremia. This was realized by PCR with regard to S. aureus, E. coli and S. uberis and the Limulus test. Detection of culturable pathogens in the blood of cows with severe clinical mastitis was rare and occurred in only one of 70 (1.4%) cases. Overall, bacterial growth was detected in 53 of 70 (75.7%) milk samples. S. uberis (22/70), E. coli (12/70) and S. aureus (4/70) were the most frequently isolated pathogens from milk of cows with severe mastitis. PCR was performed in 38 of 70 (54.3%) blood samples. PCR was positive in eight of 38 cases. S. uberis was found most frequently in six blood samples (8.6%). E. coli was found on PCR in one blood sample (1.4%). S. aureus was identified in one blood sample (1.4%). When Coliforms were detected in the quarter milk sample, a Limulus test was performed in the corresponding blood sample. In three of 15 cases, the Limulus test was positive (4.3% of samples). Further studies are needed to investigate the occurrence of bacteremia in cows with severe mastitis in a higher population size.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are Severe Mastitis Cases in Dairy Cows Associated with Bacteremia?

Brennecke¹,

Falkenberg²,

Wente³

et al. 2021

Animals

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“…The signs and symptoms of peritonitis can be supported by laboratory data, including leukocytosis, C-reactive protein increased, calcitonin and radiological findings, such as air under the diaphragm or localized fluid collections and visual examinations of images [5][6][7][8] .…”

Section: Literature Reviewmentioning

confidence: 99%

The positron emission tomography in diagnosis of abdominal sepsis

Azevedo

Nascimento²,

Medeiros

2016

J Surg Clin Res

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In the perioperative phase, sepsis is associated with high morbidity and mortality and is the most important problem for the surgeon. Critically ill patients profit from an early identification and implementation of an interdisciplinary diagnostic and therapy. The purpose of this review on septic peritonitis is to give an update on the diagnosis by the use of image examination, mainly Fluor18-FDG pet scan. Methods: The literature for this review was collected with PubMed and SciElo search using the combination of "FDG," "peritonitis" "sepsis," and the specific terms for sepsis. Results: Rapid diagnosis for sepsis is essential for patient´s survival. A bundle of studies was performed on early recognition and on new diagnostic tools for abdominal sepsis. Although surgical intervention is considered as an essential therapeutic step in abdominal sepsis therapy, the time-point of diagnostic and source control is still controversially discussed in the literature. Conclusion: Despite many efforts, mortality of abdominal septic patients remains unacceptably high, the early diagnosis of sepsis is challenging for health care providers, and high performance methods of radiographic imaging like positron emission tomography scan can be helpful in some cases. Their diagnostic impact has to be evaluated in future studies.

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“…Sepsis and septic shock are among the most alarming diseases. Every year, around 0.8 million people develop sepsis in Germany and the mortality rate is around 50% [1,2]. Since delayed or inadequate antibiotic treatment increases the mortality, fast and accurate therapy is essential for the survival of the patient [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Every year, around 0.8 million people develop sepsis in Germany and the mortality rate is around 50% [1,2]. Since delayed or inadequate antibiotic treatment increases the mortality, fast and accurate therapy is essential for the survival of the patient [2,3]. The effective therapeutic antibiotics concentration [3,4] is often missed for patients with sepsis.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Detection of the Antibiotic Ciprofloxacin by Means of Fiber Enhanced Raman Spectroscopy

et al. 2019

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Sepsis and septic shock exhibit a rapid course and a high fatality rate. Antibiotic treatment is time-critical and precise knowledge of the antibiotic concentration during the patients’ treatment would allow individual dose adaption. Over- and underdosing will increase the antimicrobial efficacy and reduce toxicity. We demonstrated that fiber enhanced Raman spectroscopy (FERS) can be used to detect very low concentrations of ciprofloxacin in clinically relevant doses, down to 1.5 µM. Fiber enhancement was achieved in bandgap shifted photonic crystal fibers. The high linearity between the Raman signals and the drug concentrations allows a robust calibration for drug quantification. The needed sample volume was very low (0.58 µL) and an acquisition time of 30 s allowed the rapid monitoring of ciprofloxacin levels in a less invasive way than conventional techniques. These results demonstrate that FERS has a high potential for clinical in-situ monitoring of ciprofloxacin levels.

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Bakteriämie und Sepsis

Cited by 17 publications

References 31 publications

Are Severe Mastitis Cases in Dairy Cows Associated with Bacteremia?

Are Severe Mastitis Cases in Dairy Cows Associated with Bacteremia?

The positron emission tomography in diagnosis of abdominal sepsis

Highly Sensitive Detection of the Antibiotic Ciprofloxacin by Means of Fiber Enhanced Raman Spectroscopy

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