Bakers’ yeast catalyzed synthesis of benzothiazoles in an organic medium

A splendid method for synthesis of 2-(benzothiazole)-3-phenyl acrylonitrile derivatives catalysed by piperdine

“…In the recent past, the reactions catalyzed by silica gel [18], iodine [19] and Backer's yeast [20] have also been reported for the synthesis of benzothiazole derivatives. However, many of these methods are associated with disadvantages such as long reaction time, drastic reaction conditions, expensive reagents, low yields and tedious work-up procedures.…”

Synthesis of 2-Arylbenzothiazoles Catalyzed by Biomimetic Catalyst, β-Cyclodextrin

“…15 Unfortunately, many of these existing methods, used for the synthesis of benzothiazoles accompanying with one or other kinds of the disadvantages, such as, use of volatile organic solvents, costly air sensitive reagents, 11a prolonged reaction time, 16 multistep reaction sequences, 15 high reaction temperature, 11e requirement of extreme pH, 15d,15e tedious work-up procedures, 11e and generation of solid wastes. 17 Therefore, more attention has been directed to overcome the above limitations by providing an efficient and convenient protocol for the synthesis of 2-substituted benzothiazoles. 17 Recently, more efforts have been put on the use of biocatalysts i.e.…”

“…17 Therefore, more attention has been directed to overcome the above limitations by providing an efficient and convenient protocol for the synthesis of 2-substituted benzothiazoles. 17 Recently, more efforts have been put on the use of biocatalysts i.e. functional enzymes as excellent catalysts 18 to accelerate organic transformations because of their specificity and selectivity.…”

“…18 However, it is not always preferable to use the enzymes as a catalysts in the synthetic protocols, mainly due to their high cost, 19 waste management problems, 17 less availability of pure enzymes, narrow substrate specificity and requirement of complicated co-substrates such as co-factors. 20 Recently, we have reported the use of whole cell biocatalyst 17 in the synthesis of benzothiazoles. There it was noticed that the route has been found to give good yields of the benzothiazoles after prolonged reaction time.…”

“…Inspired by these attractive features of cyclodextrin as a biomimic i.e., biomimetic catalyst and as a part of our drive towards the syntheses of bioactive molecules accelerated by biocatalysts 17 /biomimetic catalysts, and to remove the hurdles in the traditional routes of benzothiazoles, here we report for the first time biomimetic route for the synthesis of 2-substituted ben- zothiazoles by carrying the cyclocondensation of 2-aminothiophenol and aryl/heteryl aldehydes in aqueous β-cyclodextrin.…”