Baihui (DU20), Shenmen (HT7) and Sanyinjiao (SP6) target the cAMP/CREB/BDNF and PI3K/Akt pathways to reduce central nervous system apoptosis in rats with insomnia

Cao, Fuliang; Xu, Yan; Zhang, Min; Li, Xiaohui; Chen, Yizhen; Zhi, Mujun; Li, Yan

doi:10.1016/j.heliyon.2022.e12574

Cited by 17 publications

(12 citation statements)

References 44 publications

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“…The expression of Bcl-2 was upregulated, whereas Bax, Bad and Caspase-3 were downregulated. EA affects the TrkB, PI3K/Akt, and cAMP/CREB/BDNF pathways ( Cao et al, 2022 ). The anti-insomnia effect of MMWA has been observed in rats with insomnia as MMWA treatment decreased ACh and NE levels and increased 5-HT and GABA levels in the serum.…”

Section: Resultsmentioning

confidence: 99%

The effects of acupuncture on sleep disorders and its underlying mechanism: a literature review of rodent studies

Lee

Kim

2023

Front. Neurosci.

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Sleep is a set of physiological processes mainly under neurobiological regulation that affect several physiological systems, and sleep disorders are a condition where normal sleep patterns are disturbed. Clinical studies have confirmed the effects of acupuncture on sleep duration and quality. Although many studies have explored the therapeutic effects of acupuncture on sleep disorders, the mechanisms are unclear. We investigated the mechanism of acupuncture efficacy in a rodent model of sleep disorders and evaluated the therapeutic effects of acupuncture treatment. According to our results, sleep disorders are associated with several brain regions and neurotransmitters. Furthermore, this review showed that neurological processes, such as catecholamine and BDNF signaling pathways, can be regulated by acupuncture, which is a crucial aspect of the acupuncture mechanism in sleep disorders.

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Section: Resultsmentioning

confidence: 99%

The effects of acupuncture on sleep disorders and its underlying mechanism: a literature review of rodent studies

Lee

Kim

2023

Front. Neurosci.

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Section: Acupuncture or Electro-acupuncturementioning

confidence: 99%

“…In particular, Porphyromonas gingivalis, a member of the Porphyromonas family, has been shown to cause dysfunction of the cerebral lymphatic system [ 15 ]. The specific acupuncture points vary for different diseases, including Baihui (DU20) [ 320 , 321 ], Hegu (LI4) [ 322 , 323 ], and Zusanli (ST36) [ 324 , 325 ]. The application of acupuncture or electroacupuncture in the middle of the treatment process has good prospects, but still needs to be further explored.…”

Section: Potential Implications For Disease Pathogenesis and Therapeu...mentioning

confidence: 99%

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

Zhao¹,

Sun²,

Zhang³

et al. 2024

Aging and disease

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As a recently discovered waste removal system in the brain, cerebral lymphatic system is thought to play an important role in regulating the homeostasis of the central nervous system. Currently, more and more attention is being focused on the cerebral lymphatic system. Further understanding of the structural and functional characteristics of cerebral lymphatic system is essential to better understand the pathogenesis of diseases and to explore therapeutic approaches. In this review, we summarize the structural components and functional characteristics of cerebral lymphatic system. More importantly, it is closely associated with peripheral system diseases in the gastrointestinal tract, liver, and kidney. However, there is still a gap in the study of the cerebral lymphatic system. However, we believe that it is a critical mediator of the interactions between the central nervous system and the peripheral system.

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“…BDNF activates cAMP-response element binding (CREB) and causes the neurotransmitter 5-HT to be released. 55 The integrity of the intestinal epithelium is considered to be the first line of defense of the gastrointestinal tract, and insomnia may compromise the intestinal epithelial barrier. 56 Notably, the histological analysis confirmed that insomnia caused ideal barrier damage and hypothalamic neuron disorder, and the pathological situation improved after GM intervention.…”

Section: Paper Food and Functionmentioning

confidence: 99%

Goat and cow milk differ in altering the microbiota composition and neurotransmitter levels in insomnia mouse models

Mo¹,

Jing²,

Du³

et al. 2023

Food Funct.

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Baihui (DU20), Shenmen (HT7) and Sanyinjiao (SP6) target the cAMP/CREB/BDNF and PI3K/Akt pathways to reduce central nervous system apoptosis in rats with insomnia

Cited by 17 publications

References 44 publications

The effects of acupuncture on sleep disorders and its underlying mechanism: a literature review of rodent studies

The effects of acupuncture on sleep disorders and its underlying mechanism: a literature review of rodent studies

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

Goat and cow milk differ in altering the microbiota composition and neurotransmitter levels in insomnia mouse models

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