Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets

Abstract

This study aimed to investigate the beneficial effect of baicalin–zinc complex (BZN) on intestinal microorganisms in deoxynivalenol (DON)-challenged piglets and the association between intestinal microorganisms and host immunity and hormone secretion. Forty weaned piglets were randomly divided into four treatments with 10 piglets in each treatment: (1) control (Con) group (pigs fed basal diet); (2) DON group (pigs fed 4 mg DON/kg basal diet); (3) BZN group (pigs fed 0.5% BZN basal diet); and (4) DBZN group (pigs fed 4 mg DON/kg and 0.5% BZN basal diet). The experiment lasted for 14 days. The BZN supplementation in DON-contaminated diets changed the intestinal microbiota composition and increased intestinal microbial richness and diversity of piglets. The BZN supplementation in DON-contaminated diets also alleviated the inflammatory responses of piglets and modulated the secretion of hormones related to the growth axis. Moreover, microbiota composition was associated with inflammatory and hormone secretion. In conclusion, BZN alleviated inflammatory response and hormone secretion in piglets, which is associated with the intestinal microbiome.

Intrauterine Growth Retardation Affects Intestinal Health of Suckling Piglets via Altering Intestinal Antioxidant Capacity, Glucose Uptake, Tight Junction, and Immune Responses

“…In addition, the immune and inflammatory response is closely associated with intestinal barrier function [ 52 , 53 ]. sIgA, an immunoglobulin secreted by plasma cells of the intestinal mucosa, is a major effector of the intestinal mucosal immunity, which acts as the first defense line to prevent the colonization of pathogens in the intestinal mucosa and plays an important role in local anti-infection of the body [ 24 , 54 ].…”

Discovery of metal complexes with antibacterial properties in aqueous extracts of Radix scutellariae and a study of the antibacterial properties of the baicalin–manganese complex

“…Recent research has synthesized complexes of baicalin with a variety of metal ions, and activity studies have demonstrated that all of these metal complexes are significantly more active than baicalin. For example, baicalin–zinc 35 and baicalin–copper 36 can increase the diversity of intestinal flora in experimental animals and reduce inflammation; baicalin–vanadium( iv ) has good anti-mutagenic 37 and antioxidant effects; 38 SMMC-7721 cells are effectively inhibited by baicalin complexes containing La, Y, Ce, and other rare-earth elements; 22 and baicalin complexes with La, Y, Al, and Cu are effective inhibitors of a wide range of bacteria and fungi. 39,40 Evidence also shows that baicalin–Zn is effective at treating chronic gastric ulcers.…”

Global distribution, toxicity to humans and animals, biodegradation, and nutritional mitigation of deoxynivalenol: A review

“…Zha et al. (2021) indicated that the baicalin–zinc complex (4 mg/kg DON and 0.5% baicalin zinc [BZN] basal diet) can alleviate the inflammatory response and modulate the secretion of hormones related to growth axis secretion in piglets.…”

“…Savi et al (2022) demonstrated that MSNs incorporated with zinc oxide (MSNs-ZnO, 1.0 mg/mL) can affect the growth of F. graminearum and the production of DON. Zha et al (2021) indicated that the baicalin-zinc complex (4 mg/kg DON and 0.5% baicalin zinc [BZN] basal diet) can alleviate the inflammatory response and modulate the secretion of hormones related to growth axis secretion in piglets.…”