Baicalin inhibits APEC-induced lung injury by regulating gut microbiota and SCFA production

Peng, Lu-Yuan; Shi, Haitao; Tan, Yue-Rong; Shen, Si-Yang; Yi, Pengfei; Shen, Haiqing; Fu, Binying

doi:10.1039/d1fo02407h

Cited by 29 publications

(10 citation statements)

References 41 publications

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“…It is broadly acknowledged that flavonoid compounds can modulate intestinal bacteria [ 44 , 45 , 47 , 90 ]. Specifically, baicalin, a plant-derived flavonoid, has a variety of biological activities, which inhibits lung injury by manipulating the production of intestinal bacteria and short-chain fatty acids [ 91 ], improves metabolic abnormalities and intestinal bacteria, and reduces diet-induced metabolic syndrome [ 92 ]. Interestingly, total flavonoids of Abelmoschus manihot effectively ameliorate the ulcerative colitis aggravated by chronic stress and improve depressive-like phenotype, disturbed intestinal flora, and intestinal barrier function in chronic stress mice [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Okra, possessing various bioactive components, is used to treat different diseases. This study sought to estimate the intervention effects of okra extract (OE) on brain-gut peptides (BGPs) and intestinal microorganisms in sleep deprivation (SD) rats. Methods. SD rat models were established using the modified multiple platform method and then treated with normal saline, diazepam tablets, or different doses of OE. Body weight and average daily water consumption of rats were recorded. Depressive behaviors of rats were assessed by the open field test and sucrose preference test. Serum levels of noradrenaline, melatonin, inflammatory factors (IL-1β/IL-6/TNF-α/IL-4/IL-10), and BGP indexes, including gastrin (GAS), motilin (MTL), 5-hydroxytryptamine (5-HT), cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were measured by ELISA. Additionally, the DNA relative contents of representative intestinal microorganisms in the collected rat feces were determined using RT-qPCR. Results. SD decreased body weight and average daily water consumption and induced depressive behaviors as well as stress and inflammatory responses in rats. SD rats exhibited lowered GAS, MTL, 5-HT, and VIP but elevated CCK and showed diminished DNA relative contents of Bacteroidetes and probiotics (Bifidobacteria and Lactobacilli) but increased Clostridium perfringens. OE at different doses ameliorated the depressive behaviors and mitigated the stress and inflammatory responses in SD rats, raised the serum contents of GAS, MTL, 5-HT, and VIP, reduced CCK level, elevated the DNA relative contents of Bacteroidetes and probiotics, but diminished Clostridium perfringens. OE exhibited similar intervention effects to diazepam tablets (positive control). Conclusion. OE exerts intervention effects on BGPs and intestinal microorganisms in SD rats.

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Section: Discussionmentioning

confidence: 99%

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Specifically, high-dose baicalin administration could increase the concentration of fecal acetic acid, propionic acid, and butyric acid (Zhu et al, 2020). In addition, in the avian pathogenic Escherichia coli-induced lung injury, Peng et al (2021) found that baicalin could inhibit injury by regulating gut microbiota and the production of SCFAs, including acetic acid, propionic acid, and butyric acid, especially acetic acid in the gut. It is reported that genistein ameliorated inflammation and insulin resistance associated with the production of acetate, propionate, and butyrate (Yang, Jia, et al, 2021).…”

Section: Short-chain Fatty Acids (Scfas)mentioning

confidence: 99%

Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

Yang,

Gao,

Farag

et al. 2023

Food Frontiers

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Flavonoids are phytochemicals that widely exist in plants, fruits, and vegetables and have a variety of activities. However, due to their complex structure, it is often rarely absorbed into the blood. Intestinal bacteria regarded as the third kind of human organ have attracted extensive attention in recent years. Complex structural flavonoids can be catabolized into low molecular weight phenolic acids under the action of intestinal bacteria and then absorbed into the blood, showing several protective effects on the body. In addition, the intake of flavonoids can also regulate the composition and function of intestinal flora. This paper comprehensively summarizes the interaction between flavonoids and intestinal flora, as well as the impact on human health, in order to provide some insights on how to combine intestinal microorganisms to select and ingest dietary polyphenols for future applications in medicine.

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“…Wu et al showed that SCAFs reduce lung damage by modulating macrophage immune responses during Klebsiella pneumoniae infection. Furthermore, Baicalin protects against avian pathogenic Escherichia coli (APEC)-induced inflammation by increasing the synthesis of SCFAs in the gut. , However, another study demonstrated antibiotic-induced microbiome depletion; hence, the lower levels of SCFAs could enervate LPS-induced acute lung injury (ALI). In this investigation, antibiotic cocktail (ABX) significantly reduced the amounts of SCFAs such as acetate and propionate in the stool samples .…”

Section: Immunomodulatory Effects Of the Scfas In Lungsmentioning

confidence: 99%

Short-Chain Fatty Acid (SCFA) as a Connecting Link between Microbiota and Gut-Lung Axis─A Potential Therapeutic Intervention to Improve Lung Health

Verma,

Bhagchandani,

Rai

et al. 2024

ACS Omega

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The microbiome is an integral part of the human gut, and it plays a crucial role in the development of the immune system and homeostasis. Apart from the gut microbiome, the airway microbial community also forms a distinct and crucial part of the human microbiota. Furthermore, several studies indicate the existence of communication between the gut microbiome and their metabolites with the lung airways, called "gut−lung axis". Perturbations in gut microbiota composition, termed dysbiosis, can have acute and chronic effects on the pathophysiology of lung diseases. Microbes and their metabolites in lung stimulate various innate immune pathways, which modulate the expression of the inflammatory genes in pulmonary leukocytes. For instance, gut microbiota-derived metabolites such as short-chain fatty acids can suppress lung inflammation through the activation of G protein-coupled receptors (free fatty acid receptors) and can also inhibit histone deacetylase, which in turn influences the severity of acute and chronic respiratory diseases. Thus, modulation of the gut microbiome composition through probiotic/prebiotic usage and fecal microbiota transplantation can lead to alterations in lung homeostasis and immunity. The resulting manipulation of immune cells function through microbiota and their key metabolites paves the way for the development of novel therapeutic strategies in improving the lung health of individuals affected with various lung diseases including SARS-CoV-2. This review will shed light upon the mechanistic aspect of immune system programming through gut and lung microbiota and exploration of the relationship between gut−lung microbiome and also highlight the therapeutic potential of gut microbiota-derived metabolites in the management of respiratory diseases.

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Baicalin inhibits APEC-induced lung injury by regulating gut microbiota and SCFA production

Abstract: Baicalin remodeled the dysbiosis of gut microbiota and increased the production of SCFAs especially acetic acid to defend APEC infection.

Cited by 29 publications

References 41 publications

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

Short-Chain Fatty Acid (SCFA) as a Connecting Link between Microbiota and Gut-Lung Axis─A Potential Therapeutic Intervention to Improve Lung Health

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