Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice

Liu, Jin; Yuan, Yinglin; Gong, Xia; Zhang, Liangke; Zhou, Qin; Wu, Shengwang; Zhang, Xue; Hu, Jun; Kuang, Ge; Yin, Xinru; Wan, Jingyuan; Yuan, Yao

doi:10.1016/j.intimp.2020.106208

Cited by 43 publications

(24 citation statements)

References 44 publications

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“…Baicalin cannot reduce pyroptosis by blocking NLR pyrin domain containing 3–gasdermin D signaling in hepatocyte induced with free fatty acids [ 129 ], but also alleviate palmitic acid-induced cytotoxicity in AML12 cells via suppression of ER stress and TXNIP/NLRP3 inflammasome activation [ 130 ]. In rodent models, baicalin can effectively protect mice against MCD induced NAFLD/NASH [ 131 ]. In addition, baicalin is also involved in the interactions of the liver-gut axis by regulating TGR5, FXR, bile acids and the microbiota, which regulates intestinal flora by promoting the production of SCFAs [ 132 ].…”

Section: Effects and Mechanisms Of Commonly Used Single Herb Drugs In Tcm On Nafldmentioning

confidence: 99%

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

et al. 2021

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Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD.

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Section: Effects and Mechanisms Of Commonly Used Single Herb Drugs In Tcm On Nafldmentioning

confidence: 99%

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

et al. 2021

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“…In the present study, MBC treatment reduced TNF-α , IL-6 , IL-8 and IL-1β levels, in addition to reduced expression of NF-κB ( Figure 4 ). Previous studies indicate that the natural compounds, baicalin [ 29 ], naringenin [ 30 ] and chicoric acid isolated from Crepidiastrum denticulatum [ 31 ] reduced NAFLD through attenuation of hepatic inflammation. Oxidative stress is the net result of an imbalance between the ROS production and antioxidant defense, which leads the liver damage in the progression of NAFLD [ 1 , 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway

Geethangili

Lin

Mersmann

et al. 2021

IJMS

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The prevalence of non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases worldwide. This study examined the potential protective effects of a naturally occurring polyphenolic compound, methyl brevifolincarboxylate (MBC) on fatty liver injury in vitro. The results showed that MBC at its non-cytotoxic concentrations, reduced lipid droplet accumulation and triglyceride (TG) levels in the oleic acid (OA)-treated human hepatocarcinoma cell line, SK-HEP-1 and murine primary hepatocytes. In OA-treated SK-HEP-1 cells and primary murine hepatocytes, MBC attenuated the mRNA expression levels of the de novo lipogenesis molecules, acetyl-coenzyme A carboxylase (Acc1), fatty acid synthase (Fasn) and sterol regulatory element binding protein 1c (Srebp1c). MBC promoted the lipid oxidation factor peroxisome proliferator activated receptor-α (Pparα), and its target genes, carnitine palmitoyl transferase 1 (Cpt1) and acyl-coenzyme A oxidase 1 (Acox1) in both the SK-HEP-1 cells and primary murine hepatocytes. The mRNA results were further supported by the attenuated protein expression of lipogenesis and lipid oxidation molecules in OA-treated SK-HEP-1 cells. The MBC increased the expression of AMP activated protein kinase (AMPK) phosphorylation. On the other hand, MBC treatment dampened the inflammatory mediator’s, tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), IL-8, and IL-1β secretion, and nuclear factor (NF)-κB expression (mRNA and protein) through reduced reactive oxygen species production in OA-treated SK-HEP-1 cells. Taken together, our results demonstrated that MBC possessed potential protective effects against NAFLD in vitro by amelioration of lipid metabolism and inflammatory markers through the AMPK/NF-κB signaling pathway.

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“…In addition, baicalin exerts an indirect antioxidant function by upregulating hepatic glutathione and superoxide dismutase levels and downregulating malondialdehyde levels in mice subjected to a high fat and high cholesterol diet [ 44 ]. Moreover, baicalin reduces systemic inflammation by blocking NLR pyrin domain containing 3–gasdermin D signaling, as demonstrated by in vitro experiments, and by the decreased release of pro-inflammatory factors via the inhibition of toll-like receptor 4 (TLR4) signaling cascade in mice [ 44 , 46 , 52 – 54 ].…”

Section: Effect Of Baicalin On Liver Diseasesmentioning

confidence: 99%

“…For example, the baicalin-loaded liposome formulation improves the lipophilicity of baicalin and further enhances its concentration in the liver [ 89 , 90 ]. Indeed, this formulation exerts a greater effect in the treatment of non-alcoholic fatty liver disease than baicalin alone [ 54 ]. In addition, Iman et al [ 74 , 91 ] used lactobionic acid-modified-chitosan lactate polymer to obtain a site-specific baicalin delivery to increase the liver targeting ability of this drug.…”

Section: Liver Targeting Strategy Of Baicalinmentioning

confidence: 99%

Pharmacological properties of baicalin on liver diseases: a narrative review

Yang

Zhang

et al. 2021

Pharmacol. Rep

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Baicalin is the main active component of Scutellaria baicalensis, widely used in traditional Chinese medicine thanks to its various pharmacological effects, such as anti-tumor, anti-inflammatory, and antibacterial properties, as well as cardiovascular, hepatic, and renal protective effect. Recently, the protective effects of baicalin on liver disease have received much more attention. Several studies showed that baicalin protects against several types of liver diseases including viral hepatitis, fatty liver disease, xenobiotic induced liver injury, cholestatic liver injury, and hepatocellular carcinoma, with a variety of pharmacological mechanisms. A comprehensive understanding of the mechanism of baicalin can provide a valuable reference for its clinical use, but up to now, no narrative review is available that summarizes the pharmacological effects of baicalin to clarify its potential use in the treatment of liver diseases. Therefore, this review summarizes the progress of baicalin research and the underlying mechanism in the treatment of various liver diseases, to promote further research and its clinical application.

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Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice

Cited by 43 publications

References 44 publications

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway

Pharmacological properties of baicalin on liver diseases: a narrative review

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