Baicalin, a metabolite of baicalein with antiviral activity against dengue virus

Abstract

Baicalin, a flavonoid derived from Scutellaria baicalensis, is the main metabolite of baicalein released following administration in different animal models and human. We previously reported the antiviral activity of baicalein against dengue virus (DENV). Here, we examined the anti-DENV properties of baicalin in vitro, and described the inhibitory potentials of baicalin at different steps of DENV-2 (NGC strain) replication. Our in vitro antiviral experiments showed that baicalin inhibited virus replication at IC50 = 13.5 ± 0.08 μg/ml with SI = 21.5 following virus internalization by Vero cells. Baicalin exhibited virucidal activity against DENV-2 extracellular particles at IC50 = 8.74 ± 0.08 μg/ml and showed anti-adsorption effect with IC50 = 18.07 ± 0.2 μg/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted.

Study on Baicalein and Genistein to Inhibit Human Cytomegalovirus Infection in Human Astrocyte

“…BAI has been studied that it exhibits various biological activities including anti-cancer [4],anti-virus [5,6],and has effect on other diseases [7,8].GEN also have been confirmed it has a wide spectrum of activities including anti-cancer [12], anti-viruses [13][14][15] and treating diabetes [16,17], etc. We found that, BAI and GEN have a certain effect on inhibiting HCMV infection in AS.…”

The Effective Preparation of Flavonoids from Scutellaria baicalensis GEORGIby Diaion HP-20 Resin

“…The pharmacological actions of Scutellariae Radix focus on the lungs and somewhat less directly on the large intestine (Yang et al, 2013). Recently, the biological activities of Scutellariae Radix have been reported on anti-bacterial effect (Yun et al, 2012), anti-virus (Moghaddam et al, 2014), anti-inflammation (Kim et al, 2009), anti-allergy (Hsieh et al, 2007, sedation (Park et al, 2006), anti-hypertensive effect (Song et al, 2013), and antioxidation (Cao et al, 2011). In the chemicophysical study of secondary metabolites in natural products, baicalein (Horvath et al, 2005), baicalin (Ohkoshi et al, 2009), chrysin (Tong et al, 2012), oroxylin-A (Ku et al, 2014), oroxylin-α-7-O- show differently effects on anti-oxidation and neuro-protective activity .…”

Antiviral Phytochemicals: An Overview

“…Approximately 2500 medicinal plant species have been recorded globally [19,20] to treat a myriad of inflictions and diseases. Polyphenols, alkaloids, flavonoids, saponins, quinones, terpenes, proanthocyanidins, lignins, tannins, polysaccharides, steroids, thiosulfonates and coumarins are prominent bioactive phytochemicals, which have been observed to combat viral infections [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] (Table 1).…”