Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice

Mu, Xin; He, Guo‐Wei; Yuan, Xia; Li, Xiaoxiu; Du, Guanhua

doi:10.1016/j.pbb.2011.01.011

Cited by 78 publications

(55 citation statements)

References 23 publications

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“…In MPTP-treated mice, baicalein improved the abnormal behavior and attenuated the decrease in dopamine level by changing dopamine catabolism and inhibiting dopamine turnover and inhibition of oxidative injury Table 1 Herbal materials (single compounds, fractions/extracts) on neurotoxic (6-OHDA, MPP + /MPTP and rotenone) models of PD. (Cheng et al, 2008;Mu et al, 2011). Another flavone chrysin isolated from Passiflora caerulea was reported to protect against MPP + injury in primary rat mesencephalic cultures (Mercer et al, 2005).…”

Section: Flavonoidsmentioning

confidence: 99%

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

Song

Sze

et al. 2012

Journal of Ethnopharmacology

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Section: Flavonoidsmentioning

confidence: 99%

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

Song

Sze

et al. 2012

Journal of Ethnopharmacology

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“…Baicalein has also been shown to protect against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria (9), and to attenuate inflammation-mediated degeneration of dopaminergic neurons (10). Furthermore, in mice models, Baicalein protects against MPTP-induced neurotoxicity (11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

Effect of total flavonoids from Scutellaria baicalensis on dopaminergic neurons in the substantia nigra

Li¹,

Xu²,

Bu³

et al. 2016

Biomedical Reports

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Abstract. The aim of the present study was to investigate the effect of Scutellaria baicalensis stem-leaf total flavonoid (SSTF) on the dopaminergic neurons in the substantia nigra in a mouse model of Parkinson's disease (PD). The mouse model was established by intravenous injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). SSTF (5 mg/kg) was administered to the mice before or after MPTP injection, and the effects of SSTF on the behavior of the mice and the dopaminergic neurons in the substantia nigra were assessed. In addition, the level of serum malondialdehyde (MDA) was measured. Following injection of MPTP, the number of dopaminergic neurons in the substantia nigra was decreased and the neurons appeared atrophic. In addition, the level of serum MDA in the MPTP mice increased. The mean behavioral scores and the number of dopaminergic neurons in the SSTF treatment groups were significantly higher than in the MPTP group (P<0.05), and the mean serum MDA levels were significantly lower (P<0.05). Thus, SSTF improves the behaviors and the numbers of dopaminergic neurons in the substantia nigra in MPTP-induced PD in mice. These beneficial effects appear to be associated with the reduction in serum MDA.

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“…n Po0.05 and nn Po0.01 compared to sham, ns compared to SAH, # Po0.05 compared to SAHþDMSO. traumatic brain injury and Parkinson's disease (Chen et al, 2008;Mu et al, 2011;van Leyen et al, 2006). Importantly, early baicalein treatment attenuates oxidative stress, cerebral vasospasm and finally improves neurological function following SAH (Kuo et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: Possible involvement of TLR4/NF-κB-mediated inflammatory pathway

Chun-xi¹,

Xie²,

Zhou³

et al. 2015

Brain Research

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Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice

Cited by 78 publications

References 23 publications

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

Effect of total flavonoids from Scutellaria baicalensis on dopaminergic neurons in the substantia nigra

Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: Possible involvement of TLR4/NF-κB-mediated inflammatory pathway

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