Baicalein Inhibits Interleukin-1β-Induced Proliferation of Human Rheumatoid Arthritis Fibroblast-like Synoviocytes

Chen, Shuo; Yang, Yang; Feng, Hui; Wang, Hehong; Zhao, Riguang; Liu, Hongbin

doi:10.1007/s10753-013-9725-9

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…Therefore, these results together with our findings suggest that the induction of CD4 + Foxp3 + Tregs by baicalein-mediated AhR activation might suppress the function of other CD4 + T cells such as Th1, Th2, and Th17. Our results were also consistent with those of previous reports, which reported the efficacy of baicalein in the treatment of atopic dermatitis (Th2-Th1 response), colitis, and rheumatoid arthritis (Th1-Th17 response)394041.…”

Section: Discussionsupporting

confidence: 93%

Baicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse model of food allergy

Bae

Shin

See

et al. 2016

Sci Rep

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The incidence of food allergy, which is triggered by allergen permeation of the gastrointestinal tract followed by a T-helper (Th) 2-mediated immune response, has been increasing annually worldwide. We examined the effects of baicalein (5,6,7-trihydroxyflavone), a flavonoid from Scutellaria baicalensis used in oriental herbal medicine, on regulatory T (Treg) cell induction and intestinal barrier function through the regulation of tight junctions in a mouse model of food allergy. An allergic response was induced by oral challenge with ovalbumin, and the incidence of allergic symptoms and T cell-related activity in the mesenteric lymph nodes were analyzed with and without the presence of baicalein. Our results demonstrated that the administration of baicalein ameliorated the symptoms of food allergy and attenuated serum IgE and effector T cells. However, Treg-related factors were up-regulated by baicalein. Furthermore, baicalein was shown to enhance intestinal barrier function through the regulation of tight junctions. We also found that baicalein treatment induced the differentiation of Treg cells via aryl hydrocarbon receptors (AhRs). Thus, the action of baicalein as an agonist of AhR can induce Treg differentiation and enhance barrier function, suggesting that baicalein might serve as an effective immune regulator derived from foods for the treatment of food allergy.

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Section: Discussionsupporting

confidence: 93%

Baicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse model of food allergy

Bae

Shin

See

et al. 2016

Sci Rep

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“…In addition, some studies have demonstrated the effects of baicalein on cisplatin sensitivity via different pathways in various cancer cells . Baicalein has also exhibited a wide range of anti‐inflammatory effects associated with airway injury, liver injury and rheumatoid arthritis . In summary, baicalein has the potential to become an ideal adjuvant therapy in the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…31,32 There is also evidence that baicalein may exert its effects via the PTEN/Akt pathway. 22,33 MicroRNAs (miRNAs) are small non-coding RNAs with lengths of [19][20][21][22][23][24][25] nucleotides that regulate the translation or degradation of target mRNA in the human body. 34 MiRNAs play an important role in the proliferation, invasion and apoptosis of malignant tumour cells and may affect resistance to cisplatin.…”

mentioning

confidence: 99%

Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR‐424‐3p and targeting PTEN/PI3K/Akt pathway

Wang

Chen

et al. 2018

J Cellular Molecular Medi

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Lung cancer is the leading cause of death in individuals with malignant disease. Non‐small‐cell lung cancer (NSCLC) is the most common type of lung cancer, and chemotherapy drugs such as cisplatin are the most widely used treatment for this disease. Baicalein is a purified flavonoid compound that has been reported to inhibit cancer cell growth and metastasis and increase sensitization to chemotherapeutic drugs via different pathways. Therefore, we assessed the effects of baicalein on the proliferation, apoptosis and cisplatin sensitivity in the NSCLC A549 and H460 cell lines and determined the pathways through which baicalein exerts its effects. Baicalein was slightly toxic to normal human bronchial NHBE cells but inhibited growth, induced apoptosis and increased cisplatin sensitivity in A549 and H460 cells. Baicalein down‐regulated miR‐424‐3p, up‐regulated PTEN expression and down‐regulated expression of PI3K and p‐Akt in A549 and H460 cells. Dual‐luciferase reporter assay demonstrated that PTEN is a target gene of miR‐424‐3p, and overexpression of miR‐424‐3p or silencing of PTEN partially attenuated the effects of baicalein on A549 and H460 cells. Taken together, we concluded that baicalein inhibits cell growth and increases cisplatin sensitivity to A549 and H460 cells via down‐regulation of miR‐424‐3p and targeting the PTEN/PI3K/Akt pathway.

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“…In additon, baicalein has been shown to attenuate MMP-1 expression in human keratinocytes [11]. Furthermore, baicalein has been reported to inhibit the proliferation of human rheumatoid arthritis fibroblast-like synoviocytes [12]. Whether baicalein possesses antiosteoarthritic properties remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes

Chen

Xiong

et al. 2015

Cell Physiol Biochem

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Background: Baicalein is a flavonoid isolated from Scutellaria baicalensis Georgi. Here, we investigated the anti-osteoarthritic effect of baicalein in vitro and in vivo. Methods: Interleukin-1 beta (IL-1β)-induced chondrocytes were treated with different concentrations of baicalein, real-time PCR and ELISA were performed to detect the matrix metalloproteinases (MMPs) expression. Western blot was used to evaluate the mitogen-activated protein kinase (MAPK) expression. In experimental osteoarthritis (OA), rabbits were treated with baicalein, gross morphological and histological assessment was performed to evaluate the cartilage damage. Results: Baicalein significantly reduced the expression of MMPs in vitro and in vivo. Moreover, baicalein significantly reduced the phosphorylation of p38 and extracellular signal regulated kinase (ERK), but not of c-Jun N-terminal kinase (JNK). In addition, intra-articular injection of baicalein ameliorated the cartilage damage in a rabbit model of OA induced by anterior cruciate ligament transection (ACLT). Conclusions: The results indicate that baicalein may be considered as a potential agent for OA treatment.

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Baicalein Inhibits Interleukin-1β-Induced Proliferation of Human Rheumatoid Arthritis Fibroblast-like Synoviocytes

Cited by 32 publications

References 26 publications

Baicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse model of food allergy

Baicalein induces CD4+Foxp3+ T cells and enhances intestinal barrier function in a mouse model of food allergy

Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR‐424‐3p and targeting PTEN/PI3K/Akt pathway

Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes

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