Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism

“…Impairment of complex I activity by rotenone led to excess ROS formation, which induced loss of ΔΨm and initiated apoptotic cell death [27,28]. It was reported that baicalein suppressed the mitochondrial dysfunction induced by hydrogen peroxide and 6-OHDA, and the initiation of the loss of ΔΨm in PC12 cells and SH-SY5Y cells, respectively [17,29]. This study confirmed these findings that baicalein inhibited ROS production and loss of ΔΨm triggered by rotenone in SH-SY5Y cells, resulting in cellular resistance against the initiating steps of apoptosis.…”

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers

“…Baicalein (Fig. 1a) is a flavonoid isolated from baikal skullcap and has been shown to have neuroprotective effects in various in vitro and in vivo PD models [12][13][14]. Those results suggest that baicalein may be a novel neuroprotective agent with multiple targets for the treatment of PD.…”

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

“…The flavone baicalein isolated from Scutellaria baicalensis has been reported to attenuate 6-OHDA-induced neurotoxicity both in vitro and in vivo through the attenuation of mitochondrial dysfunction, oxidative injury, JNK activation and caspase activation (Im et al, 2005;Lee et al, 2005;Mu et al, 2009). In MPTP-treated mice, baicalein improved the abnormal behavior and attenuated the decrease in dopamine level by changing dopamine catabolism and inhibiting dopamine turnover and inhibition of oxidative injury Table 1 Herbal materials (single compounds, fractions/extracts) on neurotoxic (6-OHDA, MPP + /MPTP and rotenone) models of PD.…”