Baicalein and wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures

Kong, Ebenezer K. C.; Huang, Yü; Sanderson, John E.; Chan, Kar-Bik; Yu, Shan; Yu, Cheuk‐Man

doi:10.5483/bmbrep.2010.43.4.297

Cited by 19 publications

(6 citation statements)

References 34 publications

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“…Baicalein and wogonin are two of the main active ingredients in the Scutellaria baicalensis Georgi. In the CFs, baicalein and wogonin treatment suppresses collagen I and collagen III expression stimulated by Ang II (Kong et al, 2010 ). They also reduce myocardial collagen volume fraction and inhibit myocardial collagen I and III mRNA expression in spontaneously hypertensive rats by mediating ERK and MMP-9 pathways (Kong et al, 2010 , 2011 ).…”

Section: Anti-fibrotic Effect Of Polyphenols On Cardiac Fibrosismentioning

confidence: 99%

Therapeutic Potential of Polyphenols in Cardiac Fibrosis

Zhang

Wei

et al. 2018

Front. Pharmacol.

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Cardiac fibrosis, in response to injury and stress, is central to a broad constellation of cardiovascular diseases. Fibrosis decreases myocardial wall compliance due to extracellular matrix (ECM) accumulation, leading to impaired systolic and diastolic function and causing arrhythmogenesis. Although some conventional drugs, such as β-blockers and renin-angiotensin-aldosterone system (RAAS) inhibitors, have been shown to alleviate cardiac fibrosis in clinical trials, these traditional therapies do not tend to target all the fibrosis-associated mechanisms, and do not hamper the progression of cardiac fibrosis in patients with heart failure. Polyphenols are present in vegetables, fruits, and beverages and had been proposed as attenuators of cardiac fibrosis in different models of cardiovascular diseases. Together with results found in the literature, we can show that some polyphenols exert anti-fibrotic and myocardial protective effects by mediating inflammation, oxidative stress, and fibrotic molecular signals. This review considers an overview of the mechanisms of cardiac fibrosis, illustrates their involvement in different animal models of cardiac fibrosis treated with some polyphenols and projects the future direction and therapeutic potential of polyphenols on cardiac fibrosis.

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Section: Anti-fibrotic Effect Of Polyphenols On Cardiac Fibrosismentioning

confidence: 99%

Therapeutic Potential of Polyphenols in Cardiac Fibrosis

Zhang

Wei

et al. 2018

Front. Pharmacol.

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“…[6][7][8] Besides, wogonin could inhibit angiogenesis, suppress collagen deposition in cardiac fibroblasts and inhibit ischemic brain injury. [9][10][11][12] There is no evidence for vascular relaxation effect of wogonin. We describe here that wogonin, unlike oroxylin A, is an endothelium-and NO-independent vasodilatory flavonoid.…”

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confidence: 99%

Vasodilatory Effect of Wogonin on the Rat Aorta and Its Mechanism Study

Zhang

Liu

et al. 2015

Biological & Pharmaceutical Bulletin

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1) These compounds might contribute to the anti-hypertensive effect collectively. However, the anti-hypertensive effect of Eucommia ulmoides OLIV. bark remains largely unclear.Pharmacological studies have revealed that Eucommia ulmoides OLIV. bark extract induce endothelium and NO-cyclic guanosine monophosphate (cGMP) dependent relaxation in the rat thoracic aorta.2) Another report demonstrated that the endothelium-dependent vascular relaxation induced by the bark extract is mediated by NO and endothelium-derived hyperpolarizing factor in small vessels.3) However, the vasorelaxing components have been unclear. Recently, we found oroxylin A and wogonin isolated from Eucommia ulmoides OLIV. bark could significantly lower the perfusion pressure.4) In the previous study, we had reported that oroxylin A could relax rat thoracic aorta and it was endothelium and NO dependent.5)The present study was undertaken to investigate vasodilatory effect of wogonin and its mechanism.Wogonin ( Fig. 1) is a flavone and has a variety of cardiovascular protective effect. It could regulate migration, proliferation and apoptosis of vascular smooth muscle cells. [6][7][8] Besides, wogonin could inhibit angiogenesis, suppress collagen deposition in cardiac fibroblasts and inhibit ischemic brain injury. [9][10][11][12] There is no evidence for vascular relaxation effect of wogonin. We describe here that wogonin, unlike oroxylin A, is an endothelium-and NO-independent vasodilatory flavonoid. One report demonstrated that wogonin offered a wide margin of safety.13) It has therapeutic potential for the treatment of cardiovascular and cerebrovascular diseases.

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“…This compound has been shown to possess a variety of biological characteristics, including antioxidative and anti‐inflammatory effects, tumour growth inhibition and protection of ischaemia/reperfusion injury . It has been proven to attenuate fibrotic activities in cardiac fibroblasts via mitogen‐activated protein kinase signalling and to suppress hepatic stellate cell migration by inhibiting monocyte chemoattractant protein‐1 expression . However, the effect of baicalein on human dermal fibroblasts (normal or exuberant) and the potential molecular mechanisms of baicalein are still unknown.…”

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confidence: 99%