Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats

Tsai, Chia‐Lin; Lin, Yueqiang; Wang, Hui‐Min David; Chou, Tz-Chong

doi:10.1016/j.jep.2014.02.010

Cited by 109 publications

(61 citation statements)

References 38 publications

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“…Increased activity of MPO is a strong indicator of neutrophil migration into the pulmonary parenchyma and the alveolar cavities (Reumaux et al;. MPO concentration has been used for estimation of LPSinduced ALI in many studies, for example, Rittirsch et al (2008), Tsai et al (2014). In the rhamnazin pretreated rats, a marked reduction in the activity of MPO was observed.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Rhamnazin on Lipopolysaccharide-Induced Acute Lung Injury and Inflammation in Rats

Xiao-ping

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Acute Lung Injury (ALI) results into severe inflammation and oxidative stress to the pulmonary tissue. Rhamnazin is a natural flavonoid and known for its antioxidant and anti-inflammatory properties. Materials and methods:The antioxidative and anti-inflammatory properties rhamnazin were tested for protection against the acute lung injury. We investigated whether rhamnazin improves the lipopolysaccharide (LPS)-induced ALI in an animal model (rat). We also studied the probable molecular mechanism of action of rhamnazin. Rhamnazin was injected intraperitoneally (i.p.) (5, 10 and 20 mg/kg) two days before intratracheal LPS challenge (5mg/kg). The changes in lung wet-to-dry weight ratio, LDH activity, pulmonary histopathology, BALF protein concentration, MPO activity, oxidative stress, cytokine production were estimated. Results:The results showed a significant attenuation of all the inflammatory parameters and a marked improvement in the pulmonary histopathology in the animal groups pretreated with rhamnazin. The rhamnazin pretreated group also showed activation of Nrf2 pathway and attenuation of ROS such as H2O2, MDA and hydroxyl ion. These results indicated that rhamnazin could attenuate the symptoms of ALI in rats due to its strong antioxidant and anti-inflammatory properties. Conclusion:The results strongly demonstrated that rhamnazin provides protection against LPS-induced ALI. The underlying mechanisms of its anti-inflammatory action may include inhibition of Nrf2 mediated antioxidative pathway.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Rhamnazin on Lipopolysaccharide-Induced Acute Lung Injury and Inflammation in Rats

Xiao-ping

et al. 2017

Afr J Tradit Complement Altern Med

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“…Inflammatory reaction also resulted in iNOS upregulation and increased NO production. The interaction of NO with O 2 -produces per- oxynitrite, which causes further damage by nitrosating cellular macromolecules [25] . LPS according to this study increased the production of TNF-α and IL-6, neutrophil infiltration, MPO activity, MDA, and NO in lung tissues of rats.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Naringenin against Lipopolysaccharide-Induced Acute Lung Injury in Rats

Fouad

Albuali²,

Jresat³

2016

Pharmacology

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Background/Aims: Lipopolysaccharide (LPS) induces acute lung injury (ALI) through oxidative stress and inflammation. Naringenin exerts antioxidant and anti-inflammatory effects. The possible protective effect of naringenin was investigated against ALI induced by LPS in rats. Methods: Rats received a single injection of LPS (5 mg/kg, i.v.). Naringenin was given for 4 consecutive days, at 2 doses (50 and 100 mg/kg/day, p.o.), starting 3 days before LPS administration. Results: LPS significantly increased wet/dry lung weight ratio, malondialdehyde, nitric oxide (NO), interleukin-6, and myeloperoxidase activity in the lung tissues. Naringenin, particularly the higher dose, significantly ameliorated the LPS-induced changes in the measured parameters. Also, naringenin markedly reduced the histopathological lung tissue injury that resulted from LPS. Naringenin significantly decreased the LPS-induced expression of nuclear factor-κB, inducible NO synthase, tumor necrosis factor-a, caspase-3, and significantly increased heat shock protein 70 expression in the lungs. Conclusion: Naringenin significantly protected against LPS-induced ALI in rats through its anti-inflammatory, antioxidant, antinitrosative, and antiapoptotic effects.

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“…In addition, Emo (Yang Z. et al, 2014; Wang T. et al, 2015), Bai and Bae (Lim et al, 2012; Ma et al, 2012; Feng et al, 2013; Tsai et al, 2014) as well affect some of those molecules. Given this investigation situation, it seems that constituents from either RR, RS, or RC can block AMPK pathway by cross-talk regulating pathway molecules.…”

Section: Pharmacodynamic Levelmentioning

confidence: 99%

San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review

et al. 2016

Front. Pharmacol.

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Inflammatory disorders underlie varieties of human diseases. San-Huang-Xie-xin-Tang (SHXXT), composed with Rhizoma Rhei (Rheum palmatum L.), Rhizoma Coptidis (Coptis chinensis Franch), and Radix Scutellaria (Scutellaria baicalensis Georgi), is a famous formula which has been widely used in the fight against inflammatory abnormalities. Mutual reinforcement is one of the basic theories of traditional Chinese medicine. Here this article reviewed and analyzed the recent research on (1) How the main constituents of SHXXT impact on inflammation-associated signaling pathway molecules. (2) The interaction between the main constituents and efflux pumps or intestinal transporters. The goal of this work was to, (1) Provide evidence to support the theory of mutual reinforcement. (2) Clarify the key targets of SHXXT and suggest which targets need further investigation. (3) Give advice for the clinical use of SHXXT to elevated the absorption of main constituents and eventually promote oral bioavailability. We search literatures in scientific databases with key words of “each main SHXXT constituent,” in combination with “each main inflammatory pathway target molecule” or each main intestinal transporter, respectively. We report the effect of five main constituents on target molecules which lies in three main inflammatory signaling pathways, we as well investigate the interaction between constituents and intestinal transporter. We conclude, (1) The synergistic effect of constituents at both levels confirm the mutual reinforcement theory of TCM as it is proven in this work. (2) The effect of main constituents on downstream targets in nuclear need more further investigation. (3) Drug elevating the absorption of rhein, berberine and baicalein can be employed to promote oral bioavailability of SHXXT.

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Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats

Cited by 109 publications

References 38 publications

Antioxidant and Anti-Inflammatory Effects of Rhamnazin on Lipopolysaccharide-Induced Acute Lung Injury and Inflammation in Rats

Antioxidant and Anti-Inflammatory Effects of Rhamnazin on Lipopolysaccharide-Induced Acute Lung Injury and Inflammation in Rats

Protective Effect of Naringenin against Lipopolysaccharide-Induced Acute Lung Injury in Rats

San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review

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