BAG S53P4 putty as bone graft substitute – a rabbit model

Abstract

Bioactive glass (BAG) S53P4 granules represent a bone augmentation biomaterial for the surgical treatment of bony defects, even in challenging conditions such as osteomyelitis. The aim of this eight-week rabbit implantation study was to evaluate the biocompatibility and bone regeneration performance of a BAG S53P4 putty formulation following its implantation into the proximal tibia bone of twenty-eight New Zealand white rabbits. BAG S53P4 putty was compared to BAG S53P4 granules (0.5-0.8 mm) to evaluate whether the synthetic putty binder influences the bone regeneration of the osteostimulative granules. The putty formulation facilitates clinical use because of its mouldability, injectability and ease of mixing with autograft. Implantation of putty and granules into proximal tibia defects resulted in good osseointegration of the two groups. Both biomaterials were biocompatible, showed high new bone formation, high vascularization and periosteal growth. No signs of disturbed bone formation were observed due to the PEG-glycerol binder in the BAG S53P4 putty. Instead, intramedullary ossification and stromal cell reaction were more advanced in the putty group compared to the control group (p = 0.001 and p < 0.001).In conclusion, the novel mouldable BAG S53P4 putty showed reliable bone regeneration in bony defects without adverse tissue or cell reactions.

In vitrodissolution of bioactive glass S53P4 microspheres

“…4 S53P4 putty (48 wt% 500-800 µm granules, 12 wt% 90-250 µm microspheres in a binder mixture of glycerol and polyethylene glycols) showed similar bone regeneration performance as S53P4 granules (500-800 µm) in implantation into rabbit tibia defects. 25 In a clinical follow-up study, the same S53P4 putty was successfully used as bone graft expander in minimally invasive lumbar interbody fusion. 22 A putty consisting of S53P4 granules (500-800 µm) and powder (< 45 µm) increased the pH of broths in antibacterial studies more than granules alone.…”

“…No references were found on modeling for CMCs, though experimental studies o ing process have been reported. Studies o derived SiC ceramic 25 and SiC/SiC c shown that porosity decreases and mecha prove with the increasing number of PIP show that increasing pyrolysis temperatu tration of SiC fillers in polycarbosilane improved mechanical properties in two-d SiC (C/SiC) composites fabricated using Starting with pyrolysis of a "cured prepreg-based composite, each processin process involves infiltration of a precera porous ceramic preform followed by a py which the polymer is converted into ceram cess modeling is focused on these two ste Modeling of infiltration of liquids in well-studied subject, especially in the where it is used to model seepage of wa soils and rocks. 29,30 The physics of resin under pressure is similar to the seepage pr lar approaches have been used also to mod into a mold containing fiber mats.…”

“…No references were found on modeling of the PIP process for CMCs, though experimental studies on this manufacturing process have been reported. Studies on polycarbosilanederived SiC ceramic 25 and SiC/SiC composite 26,27 have shown that porosity decreases and mechanical properties improve with the increasing number of PIP cycles. Zhu et al 28 show that increasing pyrolysis temperature and the concentration of SiC fillers in polycarbosilane polymer result in improved mechanical properties in two-dimensional Carbon/ SiC (C/SiC) composites fabricated using the PIP process.…”

Novel Bioactive Glass Putty (S53P4) as Bone Graft Expander in Minimally Invasive Lumbosacral Interbody Fusion

“…The rates of bioacti-Novel Bioactive Glass Putty (S53P4) as Bone Graft Expander in Minimally Invasive Lumbosacral Interbody Fusion vity and resorption of BAGs are dependent on the chemical composition, the surrounding pH, the temperature and the surface layers on the glass 24,35) . BAG S53P4 putty used in this study consists of a total of 60% by weight bioactive glass and is a synthetic, osteoconductive and osteostimulative paste-like bone void filler that was found biocompatible in our recent study 31) .…”